Greater extracellular free-water in first-episode psychosis predicts better neurocognitive functioning.
Greater extracellular free-water in first-episode psychosis predicts better neurocognitive functioning.
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DOI：
10.1038/mp.2017.43
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发表时间：
2018-03
影响因子：
11
通讯作者：
Szeszko PR
中科院分区：
文献类型：
--
作者：
Lyall AE;Pasternak O;Robinson DG;Newell D;Trampush JW;Gallego JA;Fava M;Malhotra AK;Karlsgodt KH;Kubicki M;Szeszko PR
自由水成像是一种新颖的扩散磁推理成像 (MRI) 方法，能够将影响细胞外空间的变化与反映神经元细胞和过程变化的变化区分开来。之前的一项针对精神分裂症的自由水成像研究发现，在疾病的早期阶段，细胞外水量显着增加。然而，其临床和功能后遗症尚未得到研究。在这里，我们对 63 名首发精神病患者和 70 名健康匹配对照人群应用了自由水成像，以更好地了解更多细胞外水的功能意义。我们使用扩散 MRI 数据和基于束的空间统计分析流程首先分析分数各向异性 (FA)，这是评估白质最常用的指标。然后进行自由水成像分析，其中两个参数，即细胞外自由水 (FW) 和细胞组织 FA (FA-t) 的分数体积，在各组之间的整个白质骨架中进行估计和比较，并与基线和 12 周抗精神病药物治疗后的认知测量相关。我们的结果表明，与健康对照相比，患者整个大脑的 FA 较低，这与 FW 的显着增加重叠，而 FA-t 仅减少有限。此外，在 12 周的抗精神病药物治疗后，较高的 FW 与更好的神经认知功能相关。这是第一项表明精神病首发期间细胞外水分增加的研究，这可能表明急性神经炎症过程，和/或脑水肿可能预示着更好的功能结果。
Free Water Imaging is a novel diffusion magnetic reasonance imaging (MRI) method that is able to separate changes affecting the extracellular space from those that reflect changes in neuronal cells and processes. A previous Free Water Imaging study in schizophrenia identified significantly greater extracellular water volume in the early stages of the disorder; however, it’s clinical and functional sequelae have not yet been investigated. Here, we applied Free Water Imaging to a larger cohort of 63 first-episode patients with psychosis and 70 healthy matched controls to better understand the functional significance of greater extracellular water. We used diffusion MRI data and the Tract-Based Spatial Statistics analytic pipeline to first analyze fractional anisotropy (FA), the most commonly employed metric for assessing white matter. This comparison was then followed by Free Water Imaging analysis, where two parameters, the fractional volume of extracellular free-water (FW) and cellular tissue FA (FA-t), were estimated and compared across the entire white matter skeleton between groups, and correlated with cognitive measures at baseline and following 12 weeks of antipsychotic treatment. Our results indicated lower FA across the whole brain in patients compared to healthy controls that overlap with significant increases in FW, with only limited decreases in FA-t. In addition, higher FW correlated with better neurocognitive functioning following 12 weeks of antipsychotic treatment. This is the first study to suggest that an extracellular water increase during the first-episode of psychosis, which may be indicative of an acute neuroinflammatory process, and/or cerebral edema may predict better functional outcome.
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影响因子：
5.7
作者：
Jahanshad, Neda;Kochunov, Peter V.;Sprooten, Emma;Mandl, Rene C.;Nichols, Thomas E.;Almasy, Laura;Blangero, John;Brouwer, Rachel M.;Curran, Joanne E.;de Zubicaray, Greig I.;Duggirala, Ravi;Fox, Peter T.;Hong, L. Elliot;Landman, Bennett A.;Martin, Nicholas G.;McMahon, Katie L.;Medland, Sarah E.;Mitchell, Braxton D.;Olvera, Rene L.;Peterson, Charles P.;Starr, John M.;Sussmann, Jessika E.;Toga, Arthur W.;Wardlaw, Joanna M.;Wright, Margaret J.;Pol, Hilleke E. Hulshoff;Bastin, Mark E.;McIntosh, Andrew M.;Deary, Ian J.;Thompson, Paul M.;Glahn, David C.
通讯作者：
Glahn, David C.
影响因子：
6.6
作者：
Kochunov, Peter;Hong, L. Elliot
通讯作者：
Hong, L. Elliot
影响因子：
6.7
作者：
Friston, KJ
通讯作者：
Friston, KJ
影响因子：
4.8
作者：
Albi A;Pasternak O;Minati L;Marizzoni M;Bartrés-Faz D;Bargalló N;Bosch B;Rossini PM;Marra C;Müller B;Fiedler U;Wiltfang J;Roccatagliata L;Picco A;Nobili FM;Blin O;Sein J;Ranjeva JP;Didic M;Bombois S;Lopes R;Bordet R;Gros-Dagnac H;Payoux P;Zoccatelli G;Alessandrini F;Beltramello A;Ferretti A;Caulo M;Aiello M;Cavaliere C;Soricelli A;Parnetti L;Tarducci R;Floridi P;Tsolaki M;Constantinidis M;Drevelegas A;Frisoni G;Jovicich J;PharmaCog Consortium
通讯作者：
PharmaCog Consortium
影响因子：
2.4
作者：
Ochoa S;Usall J;Cobo J;Labad X;Kulkarni J
通讯作者：
Kulkarni J