Effect of Methionine Restriction on Aging: Its Relationship to Oxidative Stress.
Effect of Methionine Restriction on Aging: Its Relationship to Oxidative Stress.
复制标题
蛋氨酸限制对衰老的影响：与氧化应激的关系。
DOI：
10.3390/biomedicines9020130
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发表时间：
2021-01-29
期刊：
影响因子：
4.7
通讯作者：
Koya D
中科院分区：
文献类型：
--
作者：
Kitada M;Ogura Y;Monno I;Xu J;Koya D
Enhanced oxidative stress is closely related to aging and impaired metabolic health and is influenced by diet-derived nutrients and energy. Recent studies have shown that methionine restriction (MetR) is related to longevity and metabolic health in organisms from yeast to rodents. The effect of MetR on lifespan extension and metabolic health is mediated partially through a reduction in oxidative stress. Methionine metabolism is involved in the supply of methyl donors such as S-adenosyl-methionine (SAM), glutathione synthesis and polyamine metabolism. SAM, a methionine metabolite, activates mechanistic target of rapamycin complex 1 and suppresses autophagy; therefore, MetR can induce autophagy. In the process of glutathione synthesis in methionine metabolism, hydrogen sulfide (H2S) is produced through cystathionine-β-synthase and cystathionine-γ-lyase; however, MetR can induce increased H2S production through this pathway. Similarly, MetR can increase the production of polyamines such as spermidine, which are involved in autophagy. In addition, MetR decreases oxidative stress by inhibiting reactive oxygen species production in mitochondria. Thus, MetR can attenuate oxidative stress through multiple mechanisms, consequently associating with lifespan extension and metabolic health. In this review, we summarize the current understanding of the effects of MetR on lifespan extension and metabolic health, focusing on the reduction in oxidative stress.
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影响因子：
20.1
作者：
Calvert JW;Jha S;Gundewar S;Elrod JW;Ramachandran A;Pattillo CB;Kevil CG;Lefer DJ
通讯作者：
Lefer DJ
DOI：
10.1186/2046-2395-3-10
发表时间：
2014
期刊：
Longevity & healthspan
影响因子：
--
作者：
Brown-Borg HM;Rakoczy S;Wonderlich JA;Armstrong V;Rojanathammanee L
通讯作者：
Rojanathammanee L
影响因子：
4.5
作者：
Caro, Pilar;Gomez, Jose;Barja, Gustavo
通讯作者：
Barja, Gustavo
影响因子：
2.9
作者：
Durando, Xavier;Thivat, Emilie;Chollet, Philippe
通讯作者：
Chollet, Philippe
影响因子：
3.5
作者：
Durando, Xavier;Farges, Marie-Chantal;Thivat, Emilie
通讯作者：
Thivat, Emilie