Macromolecules, dendrimers, and nanomaterials in magnetic resonance imaging: the interplay between size, function, and pharmacokinetics.
Macromolecules, dendrimers, and nanomaterials in magnetic resonance imaging: the interplay between size, function, and pharmacokinetics.
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DOI：
10.1021/cr900232t
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发表时间：
2010-05-12
期刊：
影响因子：
62.1
通讯作者：
Brechbiel, Martin W.
中科院分区：
文献类型：
--
作者：
Villaraza, Aaron Joseph L.;Bumb, Ambika;Brechbiel, Martin W.
医学中的磁学有着悠久而有趣的历史。公元10世纪，埃及医生和哲学家阿维森纳开出了一种溶解在牛奶中的磁铁矿颗粒，以防止意外吞噬铁锈，理由是磁铁矿会吸引有毒的铁并加速其通过肠道的排泄，从而使其成为惰性物质。1一千年后的1977年7月3日，“坚不可摧”，这台可以工作5小时才能产生一张图像的小机器，这一事件利用磁力改变了现代医学的面貌。看一看自制的超导磁体，它由30英里长的Nb-钛金属丝建造，现在位于史密森学会的正确位置，令人难以置信的是，在短短30年的时间里，磁共振成像(MRI)如何从粗糙的、几乎丑陋的人类扫描变成了医生现在可以定期从诊断工具菜单上订购MRI的地方，因为它精致的解剖分辨率，通常精确到0.5-1毫米。1987年，当这一领域首次在该杂志上发表时，3在Medline上只找到了39篇以“gado-”和“MRI”为关键词的论文。今天，在PubMed上同样的搜索检索到了超过25万条记录，其中一个重要的组成部分是磁共振造影剂的开发。人体本质上是一个超大的水瓶，大约三分之二的重量由水组成。水中的氢原子能够充当微观罗盘
Magnetism in medicine has had a long and interesting history. In the 10th century AD, Egyptian physician and philosopher Avicenna prescribed a grain of magnetite dissolved in milk for the accidental swallowing of rust, reasoning that magnetite would render the poisonous iron inert by attracting it and accelerating its excretion through the intestine. 1 A thousand years later, on July 3, 1977,“Indomitable”, the little machine that could, labored for 5 h to produce one image, an event that used magnetism to change the landscape of modern medicine. 2 Looking at the homemade superconducting magnet constructed from 30 miles of niobium-titanium wire that now resides in its rightful place at the Smithsonian Institution, it is incredible to comprehend how in a mere 30 years magnetic resonance imaging (MRI) has gone from its crude, almost ugly, human scan to where physicians can now regularly order MRIs off their menu of diagnostic tools because of its exquisite anatomical resolution, routinely down to 0.5-1 mm. When the field was first reviewed in this journal in 1987, 3 only 39 papers were found in Medline with the keywords “gado-” and “MRI”. 4 Today, this same search on PubMed pulls out over 250,000 records, of which a significant component has been development of MR contrast agents. The human body is essentially a supersized water bottle, with about two-thirds of its weight consisting of water. Water’s hydrogen atoms are able to act as microscopic compass
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DOI：
10.1002/jmri.1880040336
发表时间：
1994-05-01
期刊：
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING
影响因子：
--
作者：
ADAM, G;NEUERBURG, J;GUNTHER, RW
通讯作者：
GUNTHER, RW
影响因子：
4.3
作者：
Ali, M. Meser;Woods, Mark;Sherry, A. Dean
通讯作者：
Sherry, A. Dean
影响因子：
3
作者：
Aime, S;Botta, M;Terreno, E
通讯作者：
Terreno, E
影响因子：
3
作者：
Aime, S;Anelli, PL;Terreno, E
通讯作者：
Terreno, E
影响因子：
16.6
作者：
Aime, S;Delli Castelli, D;Terreno, E
通讯作者：
Terreno, E