Joint coding of visual input and eye/head position in V1 of freely moving mice.
Joint coding of visual input and eye/head position in V1 of freely moving mice.
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DOI：
10.1016/j.neuron.2022.08.029
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发表时间：
2022-12-07
期刊：
影响因子：
16.2
通讯作者：
Niell, Cristopher M.
中科院分区：
文献类型：
--
作者：
Parker, Philip R. L.;Abe, Elliott T. T.;Leonard, Emmalyn S. P.;Martins, Dylan M.;Niell, Cristopher M.
自然行为期间的视觉输入高度依赖于眼睛和头部的运动，但是有关眼睛和头部位置的信息如何与自由运动期间的视觉处理相结合尚不清楚，因为视觉生理学通常是在头部固定下进行的。为了解决这个问题，我们对自由移动的小鼠 V1 进行了单单元电生理学研究，同时测量小鼠的眼睛位置、头部方向和小鼠视角的视觉场景。根据这些测量结果，我们根据凝视校正的视觉输入绘制了自由运动期间的时空感受野。此外，我们发现很大一部分神经元针对眼睛和头部位置进行了调整，并且这些信号通过大多数调制神经元中的乘法机制与视觉反应相结合。这些结果为小鼠 V1 编码提供了新的见解，并且更广泛地提供了在自然条件下执行视觉生理学的范例，包括主动感知和行为学行为。帕克、阿部等。等人。记录了自由移动小鼠的神经活动以及小鼠视角的视觉输入。他们测量了自由运动期间的感受野，并显示许多神经元的视觉反应受到眼睛和头部位置的乘法调节。
Visual input during natural behavior is highly dependent on movements of the eyes and head, but how information about eye and head position is integrated with visual processing during free movement is unknown, since visual physiology is generally performed under head-fixation. To address this, we performed single-unit electrophysiology in V1 of freely moving mice while simultaneously measuring the mouse’s eye position, head orientation, and the visual scene from the mouse’s perspective. From these measures, we mapped spatiotemporal receptive fields during free movement based on the gaze-corrected visual input. Furthermore, we found a significant fraction of neurons tuned for eye and head position, and these signals were integrated with visual responses through a multiplicative mechanism in the majority of modulated neurons. These results provide new insight into coding in mouse V1, and more generally provide a paradigm for performing visual physiology under natural conditions, including active sensing and ethological behavior. Parker, Abe, et. al. recorded neural activity in freely moving mice together with visual input from the mouse’s perspective. They measured receptive fields during free movement and showed visual responses in many neurons are multiplicatively modulated by eye and head position.
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