Ceramide-induced apoptosis in fas-resistant Hodgkin's disease cell lines is caspase independent.
Ceramide-induced apoptosis in fas-resistant Hodgkin's disease cell lines is caspase independent.
复制标题
神经酰胺诱导的 fas 抗性霍奇金病细胞系细胞凋亡不依赖于 caspase。
DOI：
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发表时间：
2000
影响因子：
3.7
通讯作者：
J. Nadkarni
中科院分区：
文献类型：
--
作者：
S. Metkar;M. Anand;P. Manna;K. Naresh;J. Nadkarni
We investigated whether cell-permeable, synthetic ceramide (C6 ceramide) could induce apoptosis in Fas-resistant Hodgkin's disease (HD)-derived cell lines. Despite strongly expressing the Fas-receptor, two of three HD-derived cell lines were resistant to Fas-mediated apoptosis. This resistance to Fas could not be attributed to differential Fas isoform generation patterns between the Fas-resistant and the Fas-sensitive cell lines. The Fas-resistant cell lines did not demonstrate the presence of Fas exon 8 deletion. Bcl-2 and BclxL levels were comparable between the Fas-resistant and the Fas-sensitive cell lines. C6 ceramide could induce apoptosis in both Fas-resistant cell lines and this was associated with a decrease in BclxL level. Caspase-1, caspase-3, or pan-caspase inhibitors could not prevent ceramide-induced apoptosis. Furthur, ceramide treatment did not lead to cleavage of caspase 3 or poly(ADP-ribose) polymerase, but caused a loss in mitochondrial transmembrane potential which could not be prevented by caspase inhibitors. Thus, we conclude that ceramide-induced apoptosis in Fas-resistant HD cell lines is caspase independent.
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DOI：
10.1073/pnas.92.18.8443
发表时间：
1995-08
影响因子：
11.1
作者：
C. Tepper;S. Jayadev;Bin Liu;A. Bielawska;R. A. Wolff;S. Yonehara;Y. Hannun;M. Seldin
通讯作者：
C. Tepper;S. Jayadev;Bin Liu;A. Bielawska;R. A. Wolff;S. Yonehara;Y. Hannun;M. Seldin
CD40 参与诱导 bcl-x 可挽救 sIg 诱导的小鼠 B 细胞凋亡。
DOI：
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发表时间：
1995
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Wang,Z;Karras,JG;Howard,RG;Rothstein,TL
通讯作者：
Rothstein,TL
影响因子：
--
作者：
S. Chmura;E. Nodzenski;M. Crane;S. Virudachalam;D. Hallahan;R. Weichselbaum;J. Quintáns
通讯作者：
S. Chmura;E. Nodzenski;M. Crane;S. Virudachalam;D. Hallahan;R. Weichselbaum;J. Quintáns
影响因子：
11.2
作者：
T. Fernandes‐Alnemri;Atsushi Takahashi;R. Armstrong;J. Krebs;L. Fritz;K. Tomaselli;Lijuan Wang;Zailin Yu;C. Croce;Guy Salveson;W. Earnshaw;G. Litwack;E. Alnemri
通讯作者：
T. Fernandes‐Alnemri;Atsushi Takahashi;R. Armstrong;J. Krebs;L. Fritz;K. Tomaselli;Lijuan Wang;Zailin Yu;C. Croce;Guy Salveson;W. Earnshaw;G. Litwack;E. Alnemri
prICE：神经酰胺诱导的细胞凋亡和 Bcl-2 抑制作用的下游靶点。
DOI：
10.1042/bj3160025
发表时间：
1996
期刊：
The Biochemical journal
影响因子：
--
作者：
Smyth,MJ;Perry,DK;Zhang,J;Poirier,GG;Hannun,YA;Obeid,LM
通讯作者：
Obeid,LM