A computational model of cerebrospinal fluid production and reabsorption driven by Starling forces.
A computational model of cerebrospinal fluid production and reabsorption driven by Starling forces.
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DOI：
10.3325/cmj.2014.55.481
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发表时间：
2014-10
影响因子：
1.9
通讯作者：
Linninger AA
中科院分区：
文献类型：
--
作者：
Buishas J;Gould IG;Linninger AA
实验证据对经典的脑脊液（CSF）从脉络丛流向蛛网膜颗粒的河流模型提出了质疑。我们提出了一个新的模型，水运输通过薄壁组织从微循环驱动的Starling部队。该模型研究了渗透压对脑血管系统、细胞外间隙（ECS）、血管周围间隙（PVS）和CSF之间水转运的影响。进行了严格的文献检索，重点是改变血液或心室渗透压并测量CSF产生速率的实验。本文综述了渗透压对脑室容积和血液、脉络丛上皮和脑脊液中离子流量的影响。通过推注增加血清的渗透压完全抑制心室中新生流体流的产生。连续向脑室注射高渗溶液可使脑室容积增加125%。脑室中CSF的产生改变0.231 µL/mOsm，血清中CSF的产生改变0.835 µL/mOsm。从ECS到CSF的水通量被确定为颅内动力学的关键特征。一个完整的数学模型与所有的方程和方案进行了充分的描述，以及指导构建颅内水平衡动力学的计算模型。本文提出的模型预测了ECS、血液和CSF的渗透压对脑中水通量的影响，建立了渗透压失衡与脑积水和水肿等病理状况之间的联系。
Experimental evidence has cast doubt on the classical model of river-like cerebrospinal fluid (CSF) flow from the choroid plexus to the arachnoid granulations. We propose a novel model of water transport through the parenchyma from the microcirculation as driven by Starling forces. This model investigates the effect of osmotic pressure on water transport between the cerebral vasculature, the extracellular space (ECS), the perivascular space (PVS), and the CSF. A rigorous literature search was conducted focusing on experiments which alter the osmolarity of blood or ventricles and measure the rate of CSF production. Investigations into the effect of osmotic pressure on the volume of ventricles and the flux of ions in the blood, choroid plexus epithelium, and CSF are reviewed. Increasing the osmolarity of the serum via a bolus injection completely inhibits nascent fluid flow production in the ventricles. A continuous injection of a hyperosmolar solution into the ventricles can increase the volume of the ventricle by up to 125%. CSF production is altered by 0.231 µL per mOsm in the ventricle and by 0.835 µL per mOsm in the serum. Water flux from the ECS to the CSF is identified as a key feature of intracranial dynamics. A complete mathematical model with all equations and scenarios is fully described, as well as a guide to constructing a computational model of intracranial water balance dynamics. The model proposed in this article predicts the effects the osmolarity of ECS, blood, and CSF on water flux in the brain, establishing a link between osmotic imbalances and pathological conditions such as hydrocephalus and edema.
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影响因子：
7.3
作者：
Baehr, Carsten;Reichel, Valeska;Fricker, Gert
通讯作者：
Fricker, Gert
影响因子：
3.3
作者：
Kimelberg, HK
通讯作者：
Kimelberg, HK
影响因子：
17.1
作者：
Iliff JJ;Wang M;Liao Y;Plogg BA;Peng W;Gundersen GA;Benveniste H;Vates GE;Deane R;Goldman SA;Nagelhus EA;Nedergaard M
通讯作者：
Nedergaard M
影响因子：
4.1
作者：
HUTCHINGS, M;WELLER, RO
通讯作者：
WELLER, RO
DOI：
10.1021/je060451k
发表时间：
2007-03-01
期刊：
JOURNAL OF CHEMICAL AND ENGINEERING DATA
影响因子：
--
作者：
Ge, Xinlei;Wang, Xidong;Seetharaman, Seshadri
通讯作者：
Seetharaman, Seshadri