Distribution of hemoglobinopathy disorders in Saudi Arabia based on data from the premarital screening and genetic counseling program, 2011-2015.
Distribution of hemoglobinopathy disorders in Saudi Arabia based on data from the premarital screening and genetic counseling program, 2011-2015.
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DOI：
10.1016/j.jegh.2017.12.001
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发表时间：
2018-03
影响因子：
7.3
通讯作者：
Bashawri H
中科院分区：
文献类型：
--
作者：
Alsaeed ES;Farhat GN;Assiri AM;Memish Z;Ahmed EM;Saeedi MY;Al-Dossary MF;Bashawri H
与中东周边国家相比，沙特阿拉伯的β-地中海贫血（β-thal）和镰状细胞病（SCD）患病率被认为是最高的国家之一（分别为0.05％和4.50％）。在这项研究中，二次数据分析来自婚前筛查和遗传咨询计划（PMSGC），包括2011年2月至2015年12月期间的12,30,582人。计算了β-thal和SCD的患病率（每1000人）的携带者状态、疾病状态及其组合。在为期 5 年的研究期间，每 1000 人中 β-thal 的总体患病率为 13.6（该性状为 12.9，该疾病为 0.7）。 SCD 的患病率为 49.6（性状为 45.8，疾病为 3.8）。 β-thal 比率从 2011 年的 24.2 下降到 2015 年的 12。然而，SCD 比率保持相当稳定，范围从 2011 年的 42.3 到 2015 年的 49.8。在东部和南部地区观察到 β-thal 和 SCD 比率最高。这一结果反映了 PMSGC 的重大成就。这项研究建议进一步改进高风险地区的预防措施，并提高社区意识，以最大程度地减少这些疾病的发生率。
The prevalence rates of β-thalassemia (β-thal) and Sickle Cell Disease (SCD) in Saudi Arabia are considered one of the highest compared to surrounding countries in the Middle East (0.05% and 4.50%, respectively). In this study, Secondary data analysis was obtained from the premarital screening and genetic counseling program (PMSGC), and included 12,30,582 individuals from February 2011 to December 2015. Prevalence rates (per 1000 population) for β-thal and SCD were calculated for carrier status, disease status and their combination. During the 5-year study period, the overall prevalence rate per 1000 population for β-thal was 13.6 (12.9 for the trait and 0.7 for the disease). The prevalence rate for SCD was 49.6 (45.8 for the trait and 3.8 for the disease). Rates for β-thal were found to decrease from 24.2 in 2011, to 12 in 2015. However, SCD rates remained rather constant and ranged from 42.3 in 2011 to 49.8 in 2015. The highest rate for both β-thal and SCD was observed in the Eastern and Southern regions. This result reflects major accomplishment of the PMSGC. This study recommends further improvement in preventive measures in high-risk regions, and enhanced community awareness to provide the highest rate reduction for these disorders.
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DOI：
10.4103/0971-6866.92106
发表时间：
2011-09-01
期刊：
Indian journal of human genetics
影响因子：
--
作者：
Mehdi, Syed Riaz;Al Dahmash, Badr Abdullah
通讯作者：
Al Dahmash, Badr Abdullah
DOI：
10.4103/0971-5916.90984
发表时间：
2011-11
期刊：
The Indian journal of medical research
影响因子：
--
作者：
El-Hazmi MA;Al-Hazmi AM;Warsy AS
通讯作者：
Warsy AS
影响因子：
3.7
作者：
Coleman, Michael;Al-Zahrani, Mohammed H.;Memish, Ziad A.
通讯作者：
Memish, Ziad A.
影响因子：
1
作者：
Incebiyik, Adnan;Genc, Ahmet;Vural, Mehmet
通讯作者：
Vural, Mehmet
DOI：
10.1016/s0889-8545(01)00006-7
发表时间：
2002-06-01
影响因子：
3.2
作者：
Cao, A;Rosatelli, MC;Galanello, R
通讯作者：
Galanello, R