Serum 25-hydroxyvitamin d level and influenza vaccine immunogenicity in children and adolescents.
Serum 25-hydroxyvitamin d level and influenza vaccine immunogenicity in children and adolescents.
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DOI：
10.1371/journal.pone.0083553
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Loeb M
中科院分区：
文献类型：
--
作者：
Science M;Maguire JL;Russell ML;Smieja M;Walter SD;Loeb M
接种疫苗是预防流感的重要策略，但对疫苗接种的免疫反应可能差异很大。最近的研究表明，血清25-羟基维生素D（25[OH]D）水平与免疫功能之间存在关联。本研究的目的是确定儿童和青少年血清25（OH）D水平与流感疫苗免疫原性是否相关。我们对阿尔伯塔、萨斯喀彻温省和马尼托巴的赫特人社区接种三价流感疫苗（A/布里斯班/59/2007[H1 N1]样病毒、A/布里斯班/10/2007 [H3 N2]样病毒和B/佛罗里达/4/2006样病毒）的3至15岁儿童进行了一项前瞻性队列研究。在基线时测量血清25（OH）D水平，并使用在基线和接种后3-5周进行的血凝抑制（HAI）滴度评估免疫原性。使用逻辑回归评估血清25（OH）D水平作为连续变量和二分变量与血清保护、血清转换、几何平均滴度（GMT）倍数增加和接种后滴度之间的关系。研究共纳入391名儿童和青少年，其中221名（57%）在接种后出现HAI滴度。中位血清25（OH）D水平为61.0 nmol/L（四分位距[IQR] 50.0，71.0）。未发现血清25（OH）D水平与血清保护（接种后滴度≥40和≥320）或血清转换（接种前滴度<10的受试者接种后滴度≥40，或接种前滴度≥10的受试者接种后滴度升高4倍）之间存在相关性。在健康儿童和青少年中，血清25（OH）D水平与流感疫苗免疫原性无关。应继续在这一人群中评价其他增强流感疫苗应答的策略。血清25（OH）D水平在其他人群，特别是对流感疫苗接种反应低下的人群中的疫苗反应性中的作用，需要进一步研究。
Vaccination is an important strategy in the prevention of influenza, but immunologic response to vaccination can vary widely. Recent studies have shown an association between serum 25-hydroxyvitamin D (25[OH]D) levels and immune function. The purpose of this study was to determine if serum 25(OH)D level correlates with influenza vaccine immunogenicity in children and adolescents. We conducted a prospective cohort study of children age 3 to 15 years of age vaccinated with trivalent influenza vaccine (A/Brisbane/59/2007[H1N1]-like virus, A/Brisbane/10/2007 [H3N2]-like virus and B/Florida/4/2006-like virus) in Hutterite communities in Alberta, Saskatchewan and Manitoba. Serum 25(OH)D levels were measured at baseline and immunogenicity was assessed using hemagluttination inhibition (HAI) titers done at baseline and 3–5 weeks post vaccination. Logistic regression was used to assess the relationship between serum 25(OH)D level as both a continuous and dichotomous variable and seroprotection, seroconversion, fold increase in geometric mean titer (GMT) and post vaccination titer. A total of 391 children and adolescents were included in the study and 221 (57% had post-vaccination HAI titers. The median serum 25(OH)D level was 61.0 nmol/L (Interquartile range [IQR] 50.0, 71.0). No relationship was found between serum 25(OH)D level and seroprotection (post-vaccination titer ≥40 and ≥320) or seroconversion (post-vaccination titer ≥40 for participants with pre-vaccine titer <10 or four-fold rise in post-vaccination titer for those with a pre-vaccine titer ≥10). Serum 25(OH)D level was not associated with influenza vaccine immunogenicity in otherwise healthy children and adolescents. Other strategies to enhance influenza vaccine response should continue to be evaluated in this population. The role of serum 25(OH)D level in vaccine responsiveness in other populations, especially those hyporesponsive to influenza vaccination, requires further study.
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