A Comprehensive Prognostic and Immune Analysis of SLC41A3 in Pan-Cancer.
A Comprehensive Prognostic and Immune Analysis of SLC41A3 in Pan-Cancer.
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DOI：
10.3389/fonc.2020.586414
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发表时间：
2020
影响因子：
4.7
通讯作者：
Li JC
中科院分区：
文献类型：
--
作者：
Liu J;Zhang S;Dai W;Xie C;Li JC
SLC 41 A3作为溶质载体家族的第41个成员，参与镁的转运。SLC 41 A3在癌症预后和免疫调节中的作用很少报道。本研究旨在分析SLC 41 A3在全癌组织中的表达状况及其预后意义。SLC 41 A3的mRNA表达谱获自癌症基因组图谱（TCGA）、基因型-组织表达（GTEx）、布罗德研究所癌细胞系百科全书（CCLE）和国际癌症基因组联盟（ICGC）。采用考克斯回归和Kaplan-Meier分析评价SLC 41 A3在泛癌中的预后价值。此外，使用TCGA数据库的数据计算SLC 41 A3表达与免疫细胞浸润、免疫检查点、错配修复（MMR）、DNA甲基转移酶（DNMT）、肿瘤突变负荷（TMB）和微卫星不稳定性（MSI）之间的相关性。结果显示，SLC 41 A3在肾透明细胞癌（KIRC）中表达下调，与总生存率和肿瘤特异性死亡率相关。而SLC 41 A3在肝细胞癌中表达上调，考克斯回归分析结果显示SLC 41 A3是影响肝细胞癌预后的独立因素。同时，建立了包括SLC 41 A3和分期的列线图，并对LIHC患者的总生存期显示出良好的预测能力。此外，相关性分析表明SLC 41 A3与各种癌症中的TMB、MSI、MMR、DNMT和免疫细胞浸润显著相关。总生存率和疾病特异性生存率分析显示，在ACC、LIHC和UVM患者中，SLC 41 A3表达和免疫细胞评分、TMB和MSI的组合与临床结局显著相关。因此，我们提出SLC 41 A3可能作为癌症的潜在预后生物标志物。
SLC41A3, as a member of the 41st family of solute carriers, participates in the transport of magnesium. The role of SLC41A3 in cancer prognosis and immune regulation has rarely been reported. This study was designed to analyze the expression status and prognostic significance of SLC41A3 in pan-cancers. The mRNA expression profiles of SLC41A3 were obtained from The Cancer Genome Atlas (TCGA), the Genotype-Tissue Expression (GTEx), the Broad Institute Cancer Cell Line Encyclopedia (CCLE), and the International Cancer Genome Consortium (ICGC). The Cox regression and Kaplan-Meier analyses were used to evaluate the prognostic value of SLC41A3 in pan-cancer. Furthermore, the correlation between SLC41A3 expression and immune cells infiltration, immune checkpoint, mismatch repair (MMR), DNA methyltransferase (DNMT), tumor mutation burden (TMB), and microsatellite instability (MSI) were calculated using data form TCGA database. The results showed that the expression of SLC41A3 was down-regulated in kidney renal clear cell carcinoma (KIRC), and was associated with poor overall survival and tumor-specific mortality. Whereas, the expression of SLC41A3 was up-regulated in liver hepatocellular carcinoma (LIHC), and the results of Cox regression analysis revealed that SLC41A3 was an independent factor for LIHC prognosis. Meanwhile, a nomogram including SLC41A3 and stage was built and exhibited good predictive power for the overall survival of LIHC patients. Additionally, correlation analysis suggested a significant correlation between SLC41A3 and TMB, MSI, MMR, DNMT, and immune cells infiltration in various cancers. The overall survival and disease-specific survival analysis revealed that the combined SLC41A3 expression and immune cell score, TMB, and MSI were significantly associated with clinical outcomes in ACC, LIHC, and UVM patients. Therefore, we proposed that SLC41A3 may serve as a potential prognostic biomarker for cancer.
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影响因子：
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作者：
Leygo C;Williams M;Jin HC;Chan MWY;Chu WK;Grusch M;Cheng YY
通讯作者：
Cheng YY
影响因子：
4.8
作者：
Ko, J;Jang, SW;Na, DS
通讯作者：
Na, DS
影响因子：
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作者：
Liu, Jun;Lu, Jianjun;Li, Wenli
通讯作者：
Li, Wenli
影响因子：
64.8
作者：
Li, Feng-Yen;Chaigne-Delalande, Benjamin;Kanellopoulou, Chrysi;Davis, Jeremiah C.;Matthews, Helen F.;Douek, Daniel C.;Cohen, Jeffrey I.;Uzel, Gulbu;Su, Helen C.;Lenardo, Michael J.
通讯作者：
Lenardo, Michael J.
影响因子：
12.3
作者：
Li B;Severson E;Pignon JC;Zhao H;Li T;Novak J;Jiang P;Shen H;Aster JC;Rodig S;Signoretti S;Liu JS;Liu XS
通讯作者：
Liu XS