Long-term effects of nilvadipine against progression of the central visual field defect in retinitis pigmentosa: an extended study.
Long-term effects of nilvadipine against progression of the central visual field defect in retinitis pigmentosa: an extended study.
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DOI：
10.1155/2013/585729
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发表时间：
2013
影响因子：
--
通讯作者：
Ohguro H
中科院分区：
文献类型：
--
作者：
Nakazawa M;Suzuki Y;Ito T;Metoki T;Kudo T;Ohguro H
目的.评价尼伐地平对视网膜色素变性（RP）中心视野缺损进展的长期疗效。方法. RP患者随机分为治疗组和对照组，治疗组口服尼伐地平。以MD斜率和中心2°平均敏感度（Δ CENT 4）评价RP的进展。结果治疗组的平均MD斜率为−0.55/−0.39（右眼/左眼，n = 19）dB/年，对照组为−1.37/−1.15（右眼/左眼，n = 22）dB/年（分别为P = 0.016/0.050）。然而，在双眼中，两组之间的Δ CENT 4值没有观察到统计学差异。结论虽然我们证实尼伐地平可显著延缓中央10°视野平均MD值缺损的进展，但对RP的中央2°视野无特异性。
Purpose. To assess the long-term effects of nilvadipine on the progression of central visual field defect in retinitis pigmentosa (RP). Methods. Patients with RP were randomly divided into a treated group receiving oral nilvadipine and a control group. Progression of RP was evaluated with MD slope and the average sensitivity of the central 2° (ΔCENT4). Results. The mean MD slopes were −0.55/−0.39 (right/left eyes, n = 19) dB/year in the treated group and −1.37/−1.15 (right/left eyes, n = 22) dB/year in the control group (P = 0.016/0.050, resp.). In both eyes, however, no statistical difference was observed between the two groups for the ΔCENT4 values. Conclusion. Although we confirmed that nilvadipine significantly retarded the progression of the average of MD value defects in the central 10°, it was not specific for the central 2° of the visual field in RP.
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影响因子：
4.2
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通讯作者：
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