The Antibody Assay in Suspected Autoimmune Encephalitis From Positive Rate to Test Strategies.
The Antibody Assay in Suspected Autoimmune Encephalitis From Positive Rate to Test Strategies.
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疑似自身免疫性脑炎的抗体检测从阳性率到检测策略
DOI：
10.3389/fimmu.2022.803854
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发表时间：
2022
影响因子：
7.3
通讯作者：
Zhou H
中科院分区：
文献类型：
--
作者：
Deng Q;Liu Y;Mao Z;Chen Y;Ping Y;Zhu G;Zhao W;Hu X;Zhou H
本研究旨在分析疑似自身免疫性脑炎（SAE）的抗体检测阳性率及检测策略。2020年6月1日至2021年6月30日期间在贵州省被诊断为疑似自身免疫性脑炎且经贵州金域诊断集团有限公司检测出抗神经元自身抗体的患者，Ltd.纳入本研究。根据抗神经元抗体检测结果分析阳性率及检测策略。共纳入263例SAE患者，其中58.2%（153/263）为男性，中位年龄为33岁（1-84岁）。84%（221/263）的患者完成了血清和CSF检查。共有46.0%（121/263）的SAE患者接受了AE-6检查包。当前队列的抗体阳性率为9.9%（26/263），观察到的抗体阳性发生率为0.2/100，000（26/11，570，000，95% CI：0.15-0.30），估计发生率为0.9/100，000（95% CI：0.84-0.95）。共检测到9种不同的抗神经元抗体。抗NMDAR抗体是46.2%（12/26）的受试者中最常见的抗体，其中70.0%（7/10）为儿童，其次是抗Caspr 2抗体，占30.8%（8/26）;其余7种抗体在23.1%（6/26）的人群中检出。抗神经元抗体阳性率在年龄、性别、季节间无明显差异。人均抗体检测费用为439.30美元（SD± 195.10美元）。AE-14的总费用最高，为48.016.81美元（41.56%）。本研究描述了当前队列中AE相关抗神经元抗体的阳性率和检测策略，为临床医生在临床实践中提供依据。
The aim of this study was to analyze the positive rate and test strategies of suspected autoimmune encephalitis (SAE) based on an antibody assay. Patients who were diagnosed with suspected autoimmune encephalitis in Guizhou Province between June 1, 2020, and June 30, 2021 and who had anti-neuronal autoantibodies detected by Guizhou KingMed Diagnostics Group Co., Ltd. were included in this study. The positive rate and the test strategies were analyzed based on the results of the anti-neuronal antibody assay. A total of 263 patients with SAE were included, 58.2% (153/263) of whom were males, with a median age of 33 years (1-84 years). 84% (221/263) of all patients completed both serum and CSF tests. A total of 46.0% (121/263) of SAE patients received the AE-6 examination package. The antibody-positive rate was 9.9% (26/263) in the current cohort, with an observed incidence of antibody positive of 0.2 in 100,000 (26/11,570,000, 95% CI: 0.15-0.30), and the estimated incidence was 0.9 in 100,000 (95% CI: 0.84-0.95) of the total population. A total of 9 different anti-neuronal antibodies were detected. Anti-NMDAR antibody was the most common antibody in 46.2% (12/26) of subjects, 70.0% (7/10) of whom were children, followed by anti-Caspr2 antibody in 30.8% (8/26); the remaining 7 antibodies were detected in 23.1% (6/26) of the population. There were no obvious differences among age, sex or season in the positive rate of anti-neuronal antibodies. The cost of antibody testing per capita was $439.30 (SD±$195.10). The total cost of AE-14 was the highest at $48.016.81 (41.56%) among all examination packages. This study described the positive rate associated with AE-related anti-neuronal antibodies and test strategies in the current cohort, which provides a basis for clinicians in clinical practice.
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DOI：
10.1093/ndt/gfy202
发表时间：
2018-10-01
期刊：
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
影响因子：
--
作者：
Ronco C;Marchionna N;Brendolan A;Neri M;Lorenzin A;Martínez Rueda AJ
通讯作者：
Martínez Rueda AJ
影响因子：
9.9
作者：
Cohen, Jesse;Sotoca, Javier;Venkatesan, Arun
通讯作者：
Venkatesan, Arun
DOI：
10.1016/s1474-4422(15)00401-9
发表时间：
2016-04
期刊：
The Lancet. Neurology
影响因子：
--
作者：
Graus F;Titulaer MJ;Balu R;Benseler S;Bien CG;Cellucci T;Cortese I;Dale RC;Gelfand JM;Geschwind M;Glaser CA;Honnorat J;Höftberger R;Iizuka T;Irani SR;Lancaster E;Leypoldt F;Prüss H;Rae-Grant A;Reindl M;Rosenfeld MR;Rostásy K;Saiz A;Venkatesan A;Vincent A;Wandinger KP;Waters P;Dalmau J
通讯作者：
Dalmau J
影响因子：
11.8
作者：
Gable, Mary S.;Sheriff, Heather;Glaser, Carol A.
通讯作者：
Glaser, Carol A.
影响因子：
25.8
作者：
Steiner, Johann;Walter, Martin;Stoecker, Winfried
通讯作者：
Stoecker, Winfried