The Role of Optical Imaging in Translational Nanomedicine.
The Role of Optical Imaging in Translational Nanomedicine.
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DOI：
10.3390/jfb13030137
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发表时间：
2022-08-31
影响因子：
4.8
通讯作者：
Soenen SJ
中科院分区：
文献类型：
--
作者：
Hesemans E;Buttiens K;Manshian BB;Soenen SJ
纳米药物在过去二十年中一直是主要的研究热点，并且在广泛的临床应用中越来越多地出现。然而，为了进一步发展纳米医学领域，需要正确理解它们的生物分布。为此，迫切需要监测纳米粒子的递送和治疗效果的成像方法。目前，光学成像是研究纳米材料生物分布最常用的方法，纳米材料的独特性质和光学成像的进步可以共同产生在临床前动物模型中优化监测纳米材料的新方法。这篇综述文章旨在介绍纳米药物及其转化影响，以强调光学成像在研究纳米颗粒生物分布和监测临床前水平的递送和治疗效果方面的潜力。在介绍这两个领域之后，本文重点讨论了可用于克服光学成像的一些固有局限性的不同技术，以及这如何特别有利于纳米颗粒研究。最后，我们指出了纳米粒子目前阻碍其在临床中充分发挥潜力的一些重要关键特征，以及光学成像的进步如何帮助我们提供进一步促进临床转化和扩大纳米医学领域所需的信息。
Nanomedicines have been a major research focus in the past two decades and are increasingly emerging in a broad range of clinical applications. However, a proper understanding of their biodistribution is required to further progress the field of nanomedicine. For this, imaging methods to monitor the delivery and therapeutic efficacy of nanoparticles are urgently needed. At present, optical imaging is the most common method used to study the biodistribution of nanomaterials, where the unique properties of nanomaterials and advances in optical imaging can jointly result in novel methods for optimal monitoring of nanomaterials in preclinical animal models. This review article aims to give an introduction to nanomedicines and their translational impact to highlight the potential of optical imaging to study the biodistribution of nanoparticles and to monitor the delivery and therapeutic efficacy at the preclinical level. After introducing both domains, the review focuses on different techniques that can be used to overcome some intrinsic limitations of optical imaging and how this can specifically benefit nanoparticle studies. Finally, we point out some important key features of nanoparticles that currently hinder their full potential in the clinic and how the advances in optical imaging can help to provide us with the information needed to further boost the clinical translation and expand the field of nanomedicines.
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影响因子：
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作者：
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通讯作者：
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