Advantages and Limitations of Current Techniques for Analyzing the Biodistribution of Nanoparticles.
Advantages and Limitations of Current Techniques for Analyzing the Biodistribution of Nanoparticles.
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DOI：
10.3389/fphar.2018.00802
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发表时间：
2018
影响因子：
5.6
通讯作者：
Hua S
中科院分区：
文献类型：
--
作者：
Arms L;Smith DW;Flynn J;Palmer W;Martin A;Woldu A;Hua S
纳米药物通常是亚微米尺寸的载体材料（纳米颗粒），其封装用于预防、诊断和治疗疾病的治疗和/或成像化合物。它们越来越多地被用于克服体内的生物屏障，以改善我们将化合物递送到特定组织和器官的方式。纳米医学技术旨在改善治疗化合物的功效和毒性之间的平衡。纳米粒子是纳米医学的关键技术之一，它可以表现出物理、化学和生物学特性的组合，这些特性决定了它们在体内的行为。纳米药物转化评估的一个关键组成部分是确定动物和人类体内给药后纳米颗粒的生物分布。有一系列可用于评估纳米颗粒生物分布的技术，包括组织学、电子显微镜、液体闪烁计数（LSC）、间接测量药物浓度、体内光学成像、计算机断层扫描（CT）、磁共振成像（MRI）和核医学成像。每种技术都有其自身的优势和局限性，以及评估实时，全器官和细胞积累的能力。本文将讨论每种技术的原理和方法及其在评价纳米颗粒体内生物分布方面的优势和局限性。
Nanomedicines are typically submicrometer-sized carrier materials (nanoparticles) encapsulating therapeutic and/or imaging compounds that are used for the prevention, diagnosis and treatment of diseases. They are increasingly being used to overcome biological barriers in the body to improve the way we deliver compounds to specific tissues and organs. Nanomedicine technology aims to improve the balance between the efficacy and the toxicity of therapeutic compounds. Nanoparticles, one of the key technologies of nanomedicine, can exhibit a combination of physical, chemical and biological characteristics that determine their in vivo behavior. A key component in the translational assessment of nanomedicines is determining the biodistribution of the nanoparticles following in vivo administration in animals and humans. There are a range of techniques available for evaluating nanoparticle biodistribution, including histology, electron microscopy, liquid scintillation counting (LSC), indirectly measuring drug concentrations, in vivo optical imaging, computed tomography (CT), magnetic resonance imaging (MRI), and nuclear medicine imaging. Each technique has its own advantages and limitations, as well as capabilities for assessing real-time, whole-organ and cellular accumulation. This review will address the principles and methodology of each technique and their advantages and limitations for evaluating in vivo biodistribution of nanoparticles.
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DOI：
10.3390/ma3094681
发表时间：
2010-09-27
期刊：
Materials (Basel, Switzerland)
影响因子：
--
作者：
Jong WH;Burger MC;Verheijen MA;Geertsma RE
通讯作者：
Geertsma RE
影响因子：
16.6
作者：
Chen, Feng;Ellison, Paul A.;Lewis, Christina M.;Hong, Hao;Zhang, Yin;Shi, Sixiang;Hernandez, Reinier;Meyerand, M. Elizabeth;Barnhart, Todd E.;Cai, Weibo
通讯作者：
Cai, Weibo
DOI：
10.5539/gjhs.v8n3p72
发表时间：
2015-06-25
期刊：
Global journal of health science
影响因子：
--
作者：
Alturkistani HA;Tashkandi FM;Mohammedsaleh ZM
通讯作者：
Mohammedsaleh ZM
影响因子：
14
作者：
de Vries, Anke;Custers, Erica;Grull, Holger
通讯作者：
Grull, Holger
影响因子：
4.7
作者：
Andreozzi, Erica;Seo, Jai Woong;Louie, Angelique
通讯作者：
Louie, Angelique