No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer.
No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer.
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DOI：
10.1186/1471-2407-9-312
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发表时间：
2009-09-04
期刊：
影响因子：
3.8
通讯作者：
Couch FJ
中科院分区：
文献类型：
--
作者：
Goode EL;Szabo C;Prokunina-Olsson L;Vierkant RA;Fredericksen ZS;Collins FS;White KL;Schmidt M;Fridley BL;Couch FJ
TCF7L2 is a transcription factor involved in Wnt/β-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date. Two clinic-based case-control studies at the Mayo Clinic were assessed including 798 breast cancer cases, 843 breast cancer controls, 391 ovarian cancer cases, and 458 ovarian cancer controls. Genotyping at TCF7L2 rs12255372 used a 5' endonuclease assay, and statistical analysis used logistic regression among participants as a whole and among a priori-defined subsets. No associations with risk of breast or ovarian cancer were observed (ordinal model, p = 0.62 and p = 0.75, respectively). In addition, no associations were observed among sub-groups defined by age, BMI, family history, stage, grade, histology, or tumor behavior. Although the biology of the Wnt/β-catenin signaling pathway and prior association between rs12255372 and numerous phenotypes warranted examination of this TCF7L2 SNP, no compelling evidence for association with breast or ovarian cancer was observed.
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DOI：
10.1158/1055-9965.epi-08-0134
发表时间：
2008-08
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Wang X;Goode EL;Fredericksen ZS;Vierkant RA;Pankratz VS;Liu-Mares W;Rider DN;Vachon CM;Cerhan JR;Olson JE;Couch FJ
通讯作者：
Couch FJ
影响因子：
5.3
作者：
Bosse, Yohan;Bacot, Francois;Desrosiers, Martin
通讯作者：
Desrosiers, Martin
影响因子：
4.2
作者：
Badiglian Filho, Levon;Fujiyama Oshima, Celina Tizuko;Goncalves, Wagner Jose
通讯作者：
Goncalves, Wagner Jose
DOI：
10.1111/j.1525-1438.2007.01127.x
发表时间：
2008-09-01
影响因子：
4.8
作者：
Gatcliffe, T. A.;Monk, B. J.;Holcombe, R. F.
通讯作者：
Holcombe, R. F.
影响因子：
16.2
作者：
Folsom, Aaron R.;Pankow, James S.;Boerwinkle, Eric
通讯作者：
Boerwinkle, Eric