Lung epithelium as a sentinel and effector system in pneumonia--molecular mechanisms of pathogen recognition and signal transduction.
Lung epithelium as a sentinel and effector system in pneumonia--molecular mechanisms of pathogen recognition and signal transduction.
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肺上皮作为肺炎 - 病原体识别和信号转导的分子机制中的哨兵和效应系统。
DOI：
10.1186/1465-9921-7-97
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发表时间：
2006-07-08
影响因子：
5.8
通讯作者：
Suttorp, Norbert
中科院分区：
文献类型：
--
作者：
Hippenstiel, Stefan;Opitz, Bastian;Schmeck, Bernd;Suttorp, Norbert
肺炎是一种由多种感染源引起的常见病，在世界范围内造成了巨大的发病率和死亡率。支气管和肺上皮在宿主和环境之间有很大的表面积，是肺部感染的主要攻击目标。最近的证据表明，除了作为一种机械屏障，肺上皮细胞还发挥着对抗病原体的重要哨兵系统的作用。上皮细胞配备了跨膜和胞质的病原体感知模式识别受体，可以检测入侵的病原体。一个复杂的信号导致上皮细胞的激活，它基本上参与了随后的先天和获得性免疫反应的启动和协调。本文就病原菌检测、宿主细胞信号转导、病原菌及其毒力因子激活肺上皮细胞的分子机制等方面的研究进展作一综述，并指出有待解决的问题。对肺炎宿主反应中肺上皮细胞功能的分析可能为开发除抗生素之外的肺炎的创新治疗方法铺平道路。
Pneumonia, a common disease caused by a great diversity of infectious agents is responsible for enormous morbidity and mortality worldwide. The bronchial and lung epithelium comprises a large surface between host and environment and is attacked as a primary target during lung infection. Besides acting as a mechanical barrier, recent evidence suggests that the lung epithelium functions as an important sentinel system against pathogens. Equipped with transmembranous and cytosolic pathogen-sensing pattern recognition receptors the epithelium detects invading pathogens. A complex signalling results in epithelial cell activation, which essentially participates in initiation and orchestration of the subsequent innate and adaptive immune response. In this review we summarize recent progress in research focussing on molecular mechanisms of pathogen detection, host cell signal transduction, and subsequent activation of lung epithelial cells by pathogens and their virulence factors and point to open questions. The analysis of lung epithelial function in the host response in pneumonia may pave the way to the development of innovative highly needed therapeutics in pneumonia in addition to antibiotics.
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