Prostaglandin E(2) and interleukin-1β reduce E-cadherin expression by enhancing snail expression in gastric cancer cells.
Prostaglandin E(2) and interleukin-1β reduce E-cadherin expression by enhancing snail expression in gastric cancer cells.
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DOI：
10.3346/jkms.2012.27.9.987
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发表时间：
2012-09
影响因子：
4.5
通讯作者：
Jung KH
中科院分区：
文献类型：
--
作者：
Jee YS;Jang TJ;Jung KH
炎症与癌症的进展以及肿瘤的发生密切相关。本研究观察了前列腺素E2（PGE 2）和白细胞介素1β（IL-1β）对SNU 719胃癌细胞E-cadherin表达的影响。E-cadherin的表达随PGE 2和IL-1β作用时间和剂量的增加而降低，Snail的表达随PGE 2和IL-1β作用时间和剂量的增加而增加。PGE 2处理降低的E-cadherin表达在Snail siRNA转染后增加。用抗IL-1β抗体中和IL-1β可阻断IL-1β处理后E-cadherin和Snail的表达模式。IL-1β和PGE 2对E-cadherin和Snail的表达无协同作用。总之，炎症介质通过增强胃癌细胞中Snail的表达来降低E-cadherin的表达。炎症诱导的E-cadherin在胃癌中的转录调控对靶向化学预防和治疗具有意义。
Inflammation is closely related to the progression of cancer as well as tumorigenesis. Here, we investigated the effect of prostaglandin E2 (PGE2) and interleukin-1β (IL-1β) on E-cadherin expression in SNU719 gastric cancer cells. E-cadherin expression decreased as the dose or exposure time of PGE2 and IL-1β increased, whereas Snail expression increased with dose or time of PGE2 and IL-1β. E-cadherin expression reduced by PGE2 treatment increased after the transfection of Snail siRNA. Neutralization of IL-1β using anti-IL-1β antibody blocked the expression pattern of E-cadherin and Snail occurred by IL-1β treatment. However, there was no synergic effect of IL-1β and PGE2 on the expression pattern of E-cadherin and Snail. In conclusion, inflammatory mediators reduced E-cadherin expression by enhancing Snail expression in gastric cancer cells. Inflammation-induced transcriptional regulation of E-cadherin in gastric cancer has implications for targeted chemoprevention and therapy.
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DOI：
10.3233/clo-2009-0496
发表时间：
2009
期刊：
Cellular oncology : the official journal of the International Society for Cellular Oncology
影响因子：
--
作者：
Sitarz R;Leguit RJ;de Leng WW;Morsink FH;Polkowski WP;Maciejewski R;Offerhaus GJ;Milne AN
通讯作者：
Milne AN
影响因子：
11.2
作者：
Mann, Jason R.;Backlund, Michael G.;DuBois, Raymond N.
通讯作者：
DuBois, Raymond N.
影响因子：
11.1
作者：
Miguel Lopez-Novoa, Jose;Angela Nieto, M.
通讯作者：
Angela Nieto, M.
影响因子：
11.2
作者：
Brouxhon, Sabine;Kyrkanides, Stephanos;Pentland, Alice P.
通讯作者：
Pentland, Alice P.
影响因子：
9.7
作者：
Qian, Xuemin;Huang, Camy;Chan, Annie On On
通讯作者：
Chan, Annie On On