Associations of sleep duration and sleep-wake rhythm with lung parenchymal abnormalities on computed tomography: The MESA study.
Associations of sleep duration and sleep-wake rhythm with lung parenchymal abnormalities on computed tomography: The MESA study.
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DOI：
10.1111/jsr.13475
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发表时间：
2022-04
影响因子：
4.4
通讯作者：
Redline S
中科院分区：
文献类型：
--
作者：
Kim JS;Dashti HS;Huang T;Cade BE;Podolanczuk AJ;O'Hearn DJ;Hoffman EA;Wang H;Blaikley J;Barr RG;Redline S
在临床前模型中，昼夜节律的障碍会促进肺部炎症和纤维化。我们的目的是检查短和/或长睡眠时间和其他睡眠-觉醒模式的标志是否与成人CT上肺实质异常的更大负担有关。我们在检查5(2010-2013年)的动脉粥样硬化多种族研究中，横断面研究了活动描记捕捉到的睡眠时间与肺间质异常(n=1,111)和CT扫描高密度区(n=1,416)的相关性。我们分别对肺间质异常和高密度区的Logistic模型和线性回归模型中的潜在混杂因素进行了调整。高密度区域模型还根据研究地点、肺体积成像、辐射剂量和体重指数分层进行了调整。二次暴露是自我报告的睡眠持续时间、睡眠碎片指数、睡眠中点和时型。睡眠时间较长者(≥为8小时)的平均年龄为70岁，间质性肺异常的患病率为14%。在≥患者中，8小时睡眠时间的增加与调整后的间质肺异常风险增加相关(优势比为每1小时增加2.66，95%可信区间为1.42比4.99)。在体重指数为25 kg/m2的参与者中，较长的睡眠时间和较高的睡眠碎片指数与CT上更多的高衰减区域相关(交互作用p值为0.02)。自我报告的睡眠时间、较晚的睡眠中点和晚间时型与结果无关。基于肌动描记术的睡眠持续时间较长和睡眠碎裂与CT扫描显示的肺部异常负担较大有关。
Impairment of the circadian rhythm promotes lung inflammation and fibrosis in pre-clinical models. We aimed to examine whether short and/or long sleep duration and other markers of sleep-wake patterns are associated with a greater burden of lung parenchymal abnormalities on computed tomography among adults. We cross-sectionally examined associations of sleep duration captured by actigraphy with interstitial lung abnormalities (n=1,111) and high attenuation areas (n=1,416) on CT scan in the Multi-Ethnic Study of Atherosclerosis at Exam 5 (2010–2013). We adjusted for potential confounders in logistic and linear regression models for interstitial lung abnormalities and high attenuation area, respectively. High attenuation area models were also adjusted for study site, lung volume imaged, radiation dose, and stratified by body mass index. Secondary exposures were self-reported sleep duration, sleep fragmentation index, sleep midpoint, and chronotype. The mean age of those with longer sleep duration (≥8 hours) was 70 years and the prevalence of interstitial lung abnormalities was 14%. Increasing actigraphy-based sleep duration among participants with ≥8 hours of sleep was associated with a higher adjusted odds of interstitial lung abnormalities (odds ratio of 2.66 per 1-hour increment, 95% CI 1.42 to 4.99). Longer sleep duration and higher sleep fragmentation index were associated with more high attenuation area on CT among participants with a body mass index<25 kg/m2 (p-value for interaction<0.02). Self-reported sleep duration, later sleep midpoint, and evening chronotype were not associated with outcomes. Actigraphy-based longer sleep duration and sleep fragmentation were associated with a greater burden of lung abnormalities on CT scan.
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DOI：
10.1056/nejmoa1216076
发表时间：
2013-06-06
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hunninghake GM;Hatabu H;Okajima Y;Gao W;Dupuis J;Latourelle JC;Nishino M;Araki T;Zazueta OE;Kurugol S;Ross JC;San José Estépar R;Murphy E;Steele MP;Loyd JE;Schwarz MI;Fingerlin TE;Rosas IO;Washko GR;O'Connor GT;Schwartz DA
通讯作者：
Schwartz DA
影响因子：
3.7
作者：
Mezick, Elizabeth J.;Matthews, Karen A.;Reis, Steven E.
通讯作者：
Reis, Steven E.
影响因子：
9.6
作者：
Lancaster, Lisa H.;Mason, Wendi R.;Malow, Beth A.
通讯作者：
Malow, Beth A.
影响因子：
4.1
作者：
Hirshkowitz, Max;Whiton, Kaitlyn;Hillard, Paula J. Adams
通讯作者：
Hillard, Paula J. Adams
影响因子：
5.8
作者：
Aeschbach, D;Sher, L;Wehr, TA
通讯作者：
Wehr, TA