Toll-like receptors as modulators of mesenchymal stem cells.
Toll-like receptors as modulators of mesenchymal stem cells.
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DOI：
10.3389/fimmu.2012.00182
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发表时间：
2012
影响因子：
7.3
通讯作者：
Lombardo E
中科院分区：
文献类型：
--
作者：
Delarosa O;Dalemans W;Lombardo E
间充质干细胞（MSC）具有分化和免疫调节特性，这使它们成为治疗退行性疾病、同种异体移植排斥或炎症性和自身免疫性疾病的有趣工具。MSC的生物学特性可以通过它们在损伤或炎症部位所面临的炎症微环境来调节。事实上，骨髓间充质干细胞不会组成性地发挥其免疫调节特性，而是必须通过免疫细胞和炎症组织释放的炎症介质来启动。已经描述了MSC由Toll样受体（TLR）介导的朝向抗炎或促炎表型的极化过程。TLR与同种异体移植物排斥和慢性炎性疾病（例如，克罗恩氏病、类风湿性关节炎）通过识别损伤时产生的保守的病原体衍生的组分或内源性配体（危险信号）来治疗。在过去的几年里，对理解TLR活化对MSC的影响的兴趣大大增加，因为MSC可能会在损伤部位遇到TLR配体，并且已经证明MSC中TLR的活化可以调节其功能和治疗效果。
Mesenchymal stem cells (MSCs) have differentiation and immunomodulatory properties that make them interesting tools for the treatment of degenerative disorders, allograft rejection, or inflammatory and autoimmune diseases. Biological properties of MSCs can be modulated by the inflammatory microenvironment they face at the sites of injury or inflammation. Indeed, MSCs do not constitutively exert their immunomodulating properties but have to be primed by inflammatory mediators released from immune cells and inflamed tissue. A polarization process, mediated by Toll-like receptors (TLRs), toward either an anti-inflammatory or a pro-inflammatory phenotype has been described for MSCs. TLRs have been linked to allograft rejection and the perpetuation of chronic inflammatory diseases (e.g., Crohn’s disease, rheumatoid arthritis) through the recognition of conserved pathogen-derived components or endogenous ligands (danger signals) produced upon injury. Interest in understanding the effects of TLR activation on MSCs has greatly increased in the last few years since MSCs will likely encounter TLR ligands at sites of injury, and it has been proven that the activation of TLRs in MSCs can modulate their function and therapeutic effect.
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影响因子：
--
作者：
Gonzalez, Manuel A.;Gonzalez-Rey, Elena;Delgado, Mario
通讯作者：
Delgado, Mario
影响因子：
2.6
作者：
Bartholomew, A;Sturgeon, C;Hoffman, R
通讯作者：
Hoffman, R
DOI：
10.1152/ajpheart.01087.2009
发表时间：
2010-05-01
影响因子：
4.8
作者：
Abarbanell, Aaron M.;Wang, Yue;Meldrum, Daniel R.
通讯作者：
Meldrum, Daniel R.
影响因子：
20.3
作者：
Beyth, S;Borovsky, Z;Rachmilewitz, J
通讯作者：
Rachmilewitz, J
Toll 样受体对成体间充质干细胞活性的调节：对治疗潜力的影响。
影响因子：
4.6
作者：
DelaRosa, Olga;Lombardo, Eleuterio
通讯作者：
Lombardo, Eleuterio