Educational attainment and late life telomere length in the Health, Aging and Body Composition Study.
Educational attainment and late life telomere length in the Health, Aging and Body Composition Study.
复制标题
健康，衰老和身体成分研究中的教育程度和末期端粒长度。
DOI：
10.1016/j.bbi.2012.08.014
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发表时间：
2013-01
影响因子：
15.1
通讯作者：
Epel, Elissa
中科院分区：
文献类型：
--
作者：
Adler, Nancy;Pantell, Matthew S.;O'Donovan, Aoife;Blackburn, Elizabeth;Cawthon, Richard;Koster, Annemarie;Opresko, Patricia;Newman, Anne;Harris, Tamara B.;Epel, Elissa
在社会弱势种族/族裔群体和社会经济地位较低的群体中，发病率和死亡率较高。弱势群体更大的慢性压力暴露可能会加速细胞衰老，从而导致这一点，这与年龄调整后的端粒长度较短有关。虽然研究一致认为较短的白细胞端粒长度（LTL）与压力有关，但少数研究（主要来自英国）检查LTL与SES之间的关联，结果好坏参半。目前的研究调查了来自健康、衰老和身体成分研究的2,599名70-79岁高功能黑人和白色成年人的教育程度和LTL之间的关系。多元回归分析检测了种族/民族、教育程度和收入与LTL的相关性，并对潜在的混杂因素进行了调整。仅接受过高中教育的受试者的平均LTL（4806个碱基对）显著短于接受过高中教育的受试者（4926个碱基对; B=125，SE= 47.6，p = 0.009）。种族和教育的显著相互作用（B = 207.8，SE = 98.7，p = 0.035）显示，黑人高中后教育比白人更有益。吸烟者的LTL比不吸烟者短，但当吸烟是协变量时，教育和LTL的关联仍然显着（B = 119.7，SE = 47.6，p = 0.012）。虽然较高的收入与较长的LTL相关，但效果并不显著（p > 0.10）。这项研究首次证明了美国人口中教育程度和LTL之间的关联，在美国人口中，高等教育似乎对端粒缩短具有保护作用，特别是在黑人中。
Morbidity and mortality are greater among socially disadvantaged racial/ethnic groups and those of lower socioeconomic status (SES). Greater chronic stress exposure in disadvantaged groups may contribute to this by accelerating cellular aging, indexed by shorter age-adjusted telomere length. While studies consistently relate shorter leukocyte telomere length (LTL) to stress, the few studies, mostly from the UK, examining associations of LTL with SES have been mixed. The current study examined associations between educational attainment and LTL among 2,599 high-functioning black and white adults age 70-79 from the Health, Aging and Body Composition Study. Multiple regression analyses tested associations of race/ethnicity, educational attainment and income with LTL, adjusting for potential confounders. Those with only a high school education had significantly shorter mean LTL (4806 basepairs) than those with post-high school education (4926 basepairs; B=125, SE= 47.6, p = .009). A significant interaction of race and education (B = 207.8, SE = 98.7, p = .035) revealed more beneficial effects of post-high school education for blacks than for whites. Smokers had shorter LTL than non-smokers, but the association of education and LTL remained significant when smoking was covaried (B = 119.7, SE = 47.6, p = .012). While higher income was associated with longer LTL, the effect was not significant (p > .10). This study provides the first demonstration of an association between educational attainment and LTL in a US population where higher education appears to have a protective effect against telomere shortening, particularly in blacks.
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影响因子：
3.5
作者：
Johnson, NE
通讯作者：
Johnson, NE
影响因子：
13.6
作者：
Freund A;Orjalo AV;Desprez PY;Campisi J
通讯作者：
Campisi J
影响因子：
5.4
作者：
Crimmins, EM;Saito, Y
通讯作者：
Saito, Y
DOI：
10.1111/j.1749-6632.2009.05332.x
发表时间：
2010-01-01
期刊：
BIOLOGY OF DISADVANTAGE: SOCIOECONOMIC STATUS AND HEALTH
影响因子：
--
作者：
Matthews, Karen A.;Gallo, Linda C.;Taylor, Shelley E.
通讯作者：
Taylor, Shelley E.
影响因子：
3.1
作者：
Hatch, Stephani L.;Dohrenwend, Bruce P.
通讯作者：
Dohrenwend, Bruce P.