Understanding the significance of biological clock and its impact on cancer incidence.
Understanding the significance of biological clock and its impact on cancer incidence.
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DOI：
10.1016/j.canlet.2021.12.006
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发表时间：
2022-02-28
期刊：
影响因子：
9.7
通讯作者：
Mishra MK
中科院分区：
文献类型：
--
作者：
Malik S;Stokes Iii J;Manne U;Singh R;Mishra MK
The circadian clock is an essential timekeeper that controls, for humans, the daily rhythm of biochemical, physiological, and behavioral functions. Irregular performance or disruption in circadian rhythms results in various diseases, including cancer. As a factor in cancer development, perturbations in circadian rhythms can affect circadian homeostasis in energy balance, lead to alterations in the cell cycle, and cause dysregulation of chromatin remodeling. However, knowledge gaps remain in our understanding of the relationship between the circadian clock and cancer. Therefore, a mechanistic understanding by which circadian disruption enhances cancer risk is needed. This review article outlines the importance of the circadian clock in tumorigenesis and summarizes underlying mechanisms in the clock and its carcinogenic mechanisms, highlighting advances in chronotherapy for cancer treatment.
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