Lifestyle-dependent microglial plasticity: training the brain guardians.
Lifestyle-dependent microglial plasticity: training the brain guardians.
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DOI：
10.1186/s13062-021-00297-4
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发表时间：
2021-08-05
期刊：
影响因子：
5.5
通讯作者：
Verkhratsky A
中科院分区：
文献类型：
--
作者：
Augusto-Oliveira M;Verkhratsky A
生活方式是塑造人类最有力的工具之一；生活方式包括与环境相互作用的许多方面，从营养和教育到体育活动和睡眠质量。所有这些因素综合起来影响神经可塑性，并决定大脑的表现和认知寿命。特别是，体育锻炼、暴露于丰富的环境和节食通过对小胶质细胞的复杂修饰，改变其表型和调节其功能活动，从而将生活方式事件转化为大脑稳态的重塑和重塑神经网络，最终增强神经保护和认知寿命。
Lifestyle is one of the most powerful instruments shaping mankind; the lifestyle includes many aspects of interactions with the environment, from nourishment and education to physical activity and quality of sleep. All these factors taken in complex affect neuroplasticity and define brain performance and cognitive longevity. In particular, physical exercise, exposure to enriched environment and dieting act through complex modifications of microglial cells, which change their phenotype and modulate their functional activity thus translating lifestyle events into remodelling of brain homoeostasis and reshaping neural networks ultimately enhancing neuroprotection and cognitive longevity.
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