Elevation of fatty acid-binding protein 4 is predisposed by family history of hypertension and contributes to blood pressure elevation.
Elevation of fatty acid-binding protein 4 is predisposed by family history of hypertension and contributes to blood pressure elevation.
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DOI：
10.1038/ajh.2012.88
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发表时间：
2012-10
影响因子：
3.2
通讯作者：
Miura, Tetsuji
中科院分区：
文献类型：
--
作者：
Ota, Hideki;Furuhashi, Masato;Ishimura, Shutaro;Koyama, Masayuki;Okazaki, Yusuke;Mita, Tomohiro;Fuseya, Takahiro;Yamashita, Tomohisa;Tanaka, Marenao;Yoshida, Hideaki;Shimamoto, Kazuaki;Miura, Tetsuji
关键词：
脂肪酸结合蛋白4 （FABP4/ a - fabp /aP2）是一种脂质伴侣蛋白，在脂肪细胞和巨噬细胞中均有表达。最近的研究表明，脂肪细胞分泌FABP4，血清FABP4水平升高与肥胖、胰岛素抵抗和动脉粥样硬化有关。然而，关于FABP4在原发性高血压中的作用知之甚少。我们首先检测了18例正常血压患者（NT）和30例未治疗的原发性高血压患者（EHT）的血清FABP4浓度。根据胰岛素敏感指数M值（采用高胰岛素-血糖钳夹技术测定）将EHT分为18例胰岛素敏感型EHT （EHT- s）和12例胰岛素抵抗型EHT （EHT- r）。在第二项研究中，我们测定了30名有或没有高血压家族史的年轻NT男性（分别为FH+和FH -， n = 15）的FABP4水平。EHT-R组血清FABP4水平显著高于NT组，而EHT-S组血清FABP4水平升高无统计学意义。FABP4水平与年龄、体重指数（BMI）、血压、甘油三酯呈正相关，与M值负相关。经年龄、性别和肥胖调整后，FABP4水平是平均动脉压的独立预测因子。FH+组M值显著低于FH -组，FABP4水平显著高于FH -组，且FABP4浓度是M值的独立决定因素。在高血压患者中，FABP4有助于血压升高和动脉粥样硬化代谢表型，并且FABP4的升高与高血压家族史有关。
Fatty acid-binding protein 4 (FABP4/A-FABP/aP2), a lipid chaperone, is expressed in both adipocytes and macrophages. Recent studies have shown secretion of FABP4 from adipocytes and association of elevated serum FABP4 level with obesity, insulin resistance, and atherosclerosis. However, little is known about the role of FABP4 in essential hypertension. We first examined serum FABP4 concentrations in 18 normotensives (NT) and 30 nontreated essential hypertensives (EHT). The EHT were divided into 18 insulin-sensitive EHT (EHT-S) and 12 insulin-resistant EHT (EHT-R) based on their insulin-sensitivity index, the M value, determined by the hyperinsulinemic–euglycemic clamp technique. In the second study, we determined FABP4 levels in 30 young NT men with or without a family history of hypertension (FH+ and FH–, respectively; n = 15 each). Serum FABP4 level was significantly higher in the EHT-R than in the NT, whereas elevation of FABP4 level in the EHT-S was not statistically significant. FABP4 level was positively correlated with age, body mass index (BMI), blood pressure, and triglycerides and negatively correlated with the M value. FABP4 level was an independent predictor of mean arterial pressure after adjustment of age, gender, and adiposity. The FH+ group had a significantly lower level of M value and higher level of FABP4 than did the FH– group, and FABP4 concentration was an independent determinant of the M value. FABP4 contributes to blood pressure elevation and atherogenic metabolic phenotype in hypertensives, and the elevation of FABP4 is predisposed by a family history of hypertension.
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影响因子：
2
作者：
Furuhashi M;Ishimura S;Ota H;Miura T
通讯作者：
Miura T
血清脂肪酸结合蛋白 4 是终末期肾病心血管事件的预测因子。
影响因子：
3.7
作者：
Furuhashi M;Ishimura S;Ota H;Hayashi M;Nishitani T;Tanaka M;Yoshida H;Shimamoto K;Hotamisligil GS;Miura T
通讯作者：
Miura T
DOI：
10.1291/hypres.19.supplementi_s1
发表时间：
1996-06-01
期刊：
Hypertension research : official journal of the Japanese Society of Hypertension
影响因子：
--
作者：
Iimura, O
通讯作者：
Iimura, O
影响因子：
7.3
作者：
Lee, Mary Y. K.;Li, Huiying;Vanhoutte, Paul M.
通讯作者：
Vanhoutte, Paul M.
影响因子：
4.9
作者：
Goldstein, Iris B.;Shapiro, David;Weiss, Robert E.
通讯作者：
Weiss, Robert E.