Serum fatty acid-binding protein 4 is a predictor of cardiovascular events in end-stage renal disease.
Serum fatty acid-binding protein 4 is a predictor of cardiovascular events in end-stage renal disease.
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血清脂肪酸结合蛋白 4 是终末期肾病心血管事件的预测因子。
DOI：
10.1371/journal.pone.0027356
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Miura T
中科院分区：
文献类型：
--
作者：
Furuhashi M;Ishimura S;Ota H;Hayashi M;Nishitani T;Tanaka M;Yoshida H;Shimamoto K;Hotamisligil GS;Miura T
脂肪酸结合蛋白4(FABP4/A-FABP/aP2)是一种脂质伴侣蛋白，在脂肪细胞和巨噬细胞中均有表达。最近的研究表明，FABP4是由脂肪细胞分泌的，FABP4水平与肥胖、胰岛素抵抗和动脉粥样硬化有关。然而，FABP4浓度对预后的影响知之甚少。我们测试了FABP4水平预测终末期肾病(ESRD)患者预后的假设，ESRD是动脉粥样硬化相关发病率和死亡率的高危人群。对61例终末期肾病血液透析(HD)患者进行FABP4等生化指标检测。女性FABP_4水平(404.2±30·5 ng/ml)显著高于男性(315.8±30·0 ng/ml)，终末期肾病患者的血清FABP_4水平约为年龄、性别和体重指数相匹配的肾功能正常对照组的20倍。透析后FABP4水平下降57.2%，且与血压、BMI、血脂、胰岛素水平呈正相关。多元回归分析显示HD持续时间、BMI和甘油三酯水平是FABP4水平的独立决定因素。在7年的随访期内，FABP4水平高的终末期肾病患者的心血管死亡率较高。COX比例风险回归分析显示，经对数转换后的FABP4水平是校正了年龄、性别、HD持续时间、BMI和甘油三酯水平的心血管死亡的独立预测因素(危险比，7.75；95%CI，1.05-25.31)。这些发现表明，FABP4水平与肥胖和代谢紊乱有关，是终末期肾病心血管死亡率的新预测因子。
Fatty acid-binding protein 4 (FABP4/A-FABP/aP2), a lipid chaperone, is expressed in both adipocytes and macrophages. Recent studies have shown that FABP4 is secreted from adipocytes and that FABP4 level is associated with obesity, insulin resistance, and atherosclerosis. However, little is known about the impact of FABP4 concentrations on prognosis. We tested the hypothesis that FABP4 level predicts prognosis of patients with end-stage renal disease (ESRD), a group at high risk for atherosclerosis-associated morbidity and mortality. Biochemical markers including FABP4 were determined in 61 ESRD patients on chronic hemodialysis (HD). Serum FABP4 level in females (404.2±30.5 ng/ml) was significantly higher than that in males (315.8±30.0 ng/ml), and the levels in ESRD patients were about 20-times higher than those in age-, gender- and body mass index (BMI)-matched control subjects with normal renal function. FABP4 level was decreased by 57.2% after HD and was positively correlated with blood pressure, BMI, and levels of lipids and insulin. Multiple regression analysis indicated that HD duration, BMI, and triglycerides level were independent determinants for FABP4 level. ESRD patients with high FABP4 levels had higher cardiovascular mortality during the 7-year follow-up period. Cox proportional hazard regression analysis showed that logarithmically transformed FABP4 level was an independent predictor of cardiovascular death adjusted for age, gender, HD duration, BMI, and triglycerides level (hazard ratio, 7.75; 95% CI, 1.05–25.31). These findings suggest that FABP4 level, being related to adiposity and metabolic disorders, is a novel predictor of cardiovascular mortality in ESRD.
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影响因子：
82.9
作者：
Erbay, Ebru;Babaev, Vladimir R.;Mayers, Jared R.;Makowski, Liza;Charles, Khanichi N.;Snitow, Melinda E.;Fazio, Sergio;Wiest, Michelle M.;Watkins, Steven M.;Linton, MacRae F.;Hotamisligil, Goekhan S.
通讯作者：
Hotamisligil, Goekhan S.
影响因子：
13.6
作者：
Zoccali, C;Mallamaci, F;Matsuzawa, Y
通讯作者：
Matsuzawa, Y
影响因子：
15.9
作者：
Furuhashi, Masato;Fucho, Raquel;Hotamisligil, Goekhan S.
通讯作者：
Hotamisligil, Goekhan S.
DOI：
10.1073/pnas.0602178103
发表时间：
2006-05-02
影响因子：
11.1
作者：
Tuncman, G;Erbay, E;Hotamisligil, GS
通讯作者：
Hotamisligil, GS
影响因子：
--
作者：
Furuhashi, M;Ura, N;Shimamoto, K
通讯作者：
Shimamoto, K