Light cupula: the pathophysiological basis of persistent geotropic positional nystagmus.
Light cupula: the pathophysiological basis of persistent geotropic positional nystagmus.
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DOI：
10.1136/bmjopen-2014-006607
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发表时间：
2015-01-13
期刊：
影响因子：
2.9
通讯作者：
Inohara H
中科院分区：
文献类型：
--
作者：
Imai T;Matsuda K;Takeda N;Uno A;Kitahara T;Horii A;Nishiike S;Inohara H
为明确水平管型良性阵发性位置性眩晕（H-BPPV）患者持续性向地性位置性眼球震颤（PGN）的病理生理基础，定义了眼球震颤的时间常数（TC）及其慢相眼动速度（SPV）与仰卧位头部旋转角度的关系。通过视频眼图记录向地性或远向性位置性眼震并进行三维分析。 H-BPPV 患者的向地性位置性眼震被分类为 TC ≤ 35 s 的短暂性向地性位置性眼震或 TC > 35 s 的 PGN。或者，H-BPPV 患者持续性背地位置性眼球震颤 (AN) 的 TC >35 s。 PGN 患者的 SPV 方向与 AN 患者在中立头位范围内每个头位的 SPV 方向相反。 PGN 患者的 SPV 与头部旋转角度之间的关系与 AN 患者的 SPV 和头部旋转角度之间的关系相对于在中性头部位置上绘制的线呈线性对称。由于其 TC > 35 s，因此表明 PGN 是由每个头部位置响应重力的杯托偏差引起的。还表明，PGN 患者的眼球震颤方向与 AN 患者相反，在中性头部位置范围内，没有眼球震颤，其中眼球震颤的长轴与重力轴对齐。由于 AN 的病理生理学基础被认为是重的管帽，因此表明 PGN 是由轻的管帽反过来诱发的。
To clarify the pathophysiological basis of persistent geotropic positional nystagmus (PGN) in patients with the horizontal canal type of benign paroxysmal positional vertigo (H-BPPV), the time constant (TC) of nystagmus and the relationship between its slow phase eye velocity (SPV) and the angle of head rotation in supine were defined. Geotropic or apogeotropic positional nystagmus was recorded by video-oculography and analysed three-dimensionally. Geotropic positional nystagmuses in patients with H-BPPV were classified as transient geotropic positional nystagmus with a TC of ≤35 s or PGN with a TC of >35 s. Alternatively, the TC of persistent apogeotropic positional nystagmus (AN) in patients with H-BPPV was >35 s. The direction of the SPV of patients with PGN was opposite to that of patients with AN at each head position across the range of neutral head positions. The relationship between the SPV of patients with PGN and the angle of head rotation was linearly symmetrical against that of patients with AN with respect to a line drawn on the neutral head position. Since its TC was >35 s, it is suggested that PGN is induced by cupula deviation in response to gravity at each head position. It is also suggested that the direction of cupula deviation in patients with PGN is opposite to that of patients with AN across the neutral head positional range with no nystagmus where the long axis of cupula is in alignment with the axis of gravity. Since the pathophysiological basis of AN is considered a heavy cupula, it is suggested that PGN is conversely induced by a light cupula.
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影响因子：
2.6
作者：
Ichijo, Hiroaki
通讯作者：
Ichijo, Hiroaki
DOI：
10.1016/0957-4271(95)02040-3
发表时间：
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影响因子：
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作者：
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作者：
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