Chemical transdifferentiation: closer to regenerative medicine
Chemical transdifferentiation: closer to regenerative medicine
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化学转分化：更接近再生医学
DOI：
10.1007/s11684-016-0445-z
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发表时间：
2016-05
影响因子：
8.1
通讯作者：
Lin Cheng
中科院分区：
文献类型：
--
作者：
Aining Xu;Lin Cheng
细胞转分化直接将一种类型的分化细胞转换为另一种细胞类型，比细胞重编程更有利于产生多能细胞并将其分化为功能细胞。这个过程在再生医学中至关重要。然而，主要依赖于病毒介导的外源基因表达的细胞转化策略存在临床安全性问题。具有令人信服的优势的小分子是操纵细胞命运转换的潜在替代方案。本文简要回顾了细胞转分化的本质，综述了近年来小分子物质促进细胞转分化的研究进展。特别是，我们专注于完整的化学化合物诱导的细胞转分化，这更接近于细胞治疗的临床转化。尽管取得了这些成就，化学转分化的基础机制仍然在很大程度上是未知的。更重要的是，鉴定出能够诱导体内驻留细胞转化以修复受损组织的药物仍然是当前再生医学的最终目标。
Cell transdifferentiation, which directly switches one type of differentiated cells into another cell type, is more advantageous than cell reprogramming to generate pluripotent cells and differentiate them into functional cells. This process is crucial in regenerative medicine. However, the cell-converting strategies, which mainly depend on the virus-mediated expression of exogenous genes, have clinical safety concerns. Small molecules with compelling advantages are a potential alternative in manipulating cell fate conversion. In this review, we briefly retrospect the nature of cell transdifferentiation and summarize the current developments in the research of small molecules in promoting cell conversion. Particularly, we focus on the complete chemical compound-induced cell transdifferentiation, which is closer to the clinical translation in cell therapy. Despite these achievements, the mechanisms underpinning chemical transdifferentiation remain largely unknown. More importantly, identifying drugs that induce resident cell conversionin vivoto repair damaged tissue remains to be the end-goal in current regenerative medicine.
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影响因子：
64.5
作者：
Riddell J;Gazit R;Garrison BS;Guo G;Saadatpour A;Mandal PK;Ebina W;Volchkov P;Yuan GC;Orkin SH;Rossi DJ
通讯作者：
Rossi DJ
影响因子：
9.8
作者：
Heinrich C;Blum R;Gascón S;Masserdotti G;Tripathi P;Sánchez R;Tiedt S;Schroeder T;Götz M;Berninger B
通讯作者：
Berninger B
影响因子：
48
作者：
Kurian, Leo;Sancho-Martinez, Ignacio;Nivet, Emmanuel;Aguirre, Aitor;Moon, Krystal;Pendaries, Caroline;Volle-Challier, Cecile;Bono, Francoise;Herbert, Jean-Marc;Pulecio, Julian;Xia, Yun;Li, Mo;Montserrat, Nuria;Ruiz, Sergio;Dubova, Ilir;Rodriguez, Concepcion;Denli, Ahmet M.;Boscolo, Francesca S.;Thiagarajan, Rathi D.;Gage, Fred H.;Loring, Jeanne F.;Laurent, Louise C.;Izpisua Belmonte, Juan Carlos
通讯作者：
Izpisua Belmonte, Juan Carlos
影响因子：
23.9
作者：
Li K;Zhu S;Russ HA;Xu S;Xu T;Zhang Y;Ma T;Hebrok M;Ding S
通讯作者：
Ding S
简短的azacytidine步骤允许将悬浮液的人成纤维细胞转化为神经祖细胞样细胞。
影响因子：
2
作者：
Mirakhori F;Zeynali B;Kiani S;Baharvand H
通讯作者：
Baharvand H