Fluoride exposure and hypothyroidism in a Canadian pregnancy cohort.
Fluoride exposure and hypothyroidism in a Canadian pregnancy cohort.
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DOI：
10.1016/j.scitotenv.2022.161149
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发表时间：
2023-04-15
影响因子：
9.8
通讯作者：
Till, Christine
中科院分区：
文献类型：
--
作者：
Hall, Meaghan;Lanphear, Bruce;Chevrier, Jonathan;Hornung, Rick;Green, Rivka;Goodman, Carly;Ayotte, Pierre;Martinez-Mier, Esperanza Angeles;Zoeller, R. Thomas;Till, Christine
虽然氟化物可能会干扰甲状腺功能，但低水平氟化物暴露与甲状腺疾病之间的关系仍不清楚，特别是在怀孕期间，甲状腺激素不足会对后代发育产生不利影响。我们在加拿大的一个妊娠队列中评估了氟暴露与甲状腺功能减退之间的关系。我们测量了饮用水和三个稀释校正的尿液样本中的氟化物浓度，并根据自我报告的饮料消费量估计氟化物摄入量。我们将参加母婴环境化学品研究的妇女根据其第一个三个月的甲状腺激素水平分为甲状腺功能正常（n = 1301），亚临床甲状腺功能减退（n = 100）或原发性甲状腺功能减退（n = 107）。我们使用多项逻辑回归来估计氟化物暴露与亚临床或原发性甲状腺功能减退症分类之间的关联，并将母体甲状腺过氧化物酶抗体（TPOAb）状态（自身免疫性甲状腺功能减退症的标志物）视为效应修饰因子。在466对母子的子样本中，我们使用线性回归来探讨母亲甲状腺功能减退症与3至4岁儿童全面智商（FSIQ）之间的关系，并测试儿童性别的影响。饮用水氟浓度增加0.5 mg/L与原发性甲状腺功能减退症的几率增加1.65（95%置信区间[CI]：1.04，2.60）相关。相比之下，我们没有发现尿氟（校正比值比[aOR]：1.00; 95%CI：0.73，1.39）或氟摄入量（aOR：1.25; 95%CI：0.99，1.57）与甲状腺功能减退症之间存在显著关联。在TPOAb水平正常的妇女中，原发性甲状腺功能减退症的风险随着水氟和氟摄入量的增加而增加（aOR水氟浓度：2.85; 95%CI：1.25，6.50; aOR氟摄入量：1.75; 95%CI：1.27，2.41）。与甲状腺功能正常的女性相比，原发性甲状腺功能减退的女性所生的孩子的FSIQ评分较低，尤其是男孩（B系数：−8.42; 95% CI：−15.33，−1.50）。饮用水中的氟化物与孕妇甲状腺功能减退的风险增加有关。甲状腺破坏可能导致氟的发育神经毒性。
While fluoride can have thyroid-disrupting effects, associations between low-level fluoride exposure and thyroid conditions remain unclear, especially during pregnancy when insufficient thyroid hormones can adversely impact offspring development. We evaluated associations between fluoride exposure and hypothyroidism in a Canadian pregnancy cohort. We measured fluoride concentrations in drinking water and three dilution-corrected urine samples and estimated fluoride intake based on self-reported beverage consumption. We classified women enrolled in the Maternal-Infant Research on Environmental Chemicals Study as euthyroid (n = 1301), subclinical hypothyroid (n = 100) or primary hypothyroid (n = 107) based on their thyroid hormone levels in trimester one. We used multinomial logistic regression to estimate the association between fluoride exposure and classification of either subclinical or primary hypothyroidism and considered maternal thyroid peroxidase antibody (TPOAb) status, a marker of autoimmune hypothyroidism, as an effect modifier. In a subsample of 466 mother-child pairs, we used linear regression to explore the association between maternal hypothyroidism and child Full-Scale IQ (FSIQ) at ages 3-to-4 years and tested for effect modification by child sex. A 0.5 mg/L increase in drinking water fluoride concentration was associated with a 1.65 (95 % confidence interval [CI]: 1.04, 2.60) increased odds of primary hypothyroidism. In contrast, we did not find a significant association between urinary fluoride (adjusted odds ratio [aOR]: 1.00; 95%CI: 0.73, 1.39) or fluoride intake (aOR: 1.25; 95%CI: 0.99, 1.57) and hypothyroidism. Among women with normal TPOAb levels, the risk of primary hypothyroidism increased with both increasing water fluoride and fluoride intake (aOR water fluoride concentration: 2.85; 95%CI: 1.25, 6.50; aOR fluoride intake: 1.75; 95%CI: 1.27, 2.41). Children born to women with primary hypothyroidism had lower FSIQ scores compared to children of euthyroid women, especially among boys (B coefficient: −8.42; 95 % CI: −15.33, −1.50). Fluoride in drinking water was associated with increased risk of hypothyroidism in pregnant women. Thyroid disruption may contribute to developmental neurotoxicity of fluoride.
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影响因子：
10.4
作者：
Greer MA;Goodman G;Pleus RC;Greer SE
通讯作者：
Greer SE
影响因子：
5.2
作者：
Chatzitomaris A;Hoermann R;Midgley JE;Hering S;Urban A;Dietrich B;Abood A;Klein HH;Dietrich JW
通讯作者：
Dietrich JW
影响因子：
3.2
作者：
Collares, Fernanda M.;Korevaar, Tim I. M.;Gaillard, Romy
通讯作者：
Gaillard, Romy
DOI：
10.1002/tera.1420340211
发表时间：
1986-10-01
期刊：
TERATOLOGY
影响因子：
--
作者：
KANG, YJ;ZOLNA, L;MANSON, JM
通讯作者：
MANSON, JM
影响因子：
26.1
作者：
Green, Rivka;Lanphear, Bruce;Till, Christine
通讯作者：
Till, Christine