Pulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant in Syrian golden hamsters.
Pulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant in Syrian golden hamsters.
复制标题
DOI：
10.1080/22221751.2022.2095932
复制
发表时间：
2022-12
影响因子：
13.2
通讯作者：
中科院分区：
文献类型：
--
作者：
Omicron BA.1(B.1.1.529)SARS-CoV-2变种的特点是病毒基因组中有大量突变，与免疫逃逸和病毒传播增加有关。目前尚不清楚在人类感染奥米克龙BA.1后观察到的较轻微的新冠肺炎疾病进展是由于病毒的致病性降低，还是由于接种疫苗或以前感染的原有免疫力所致。在这里，我们用Omicron BA.1接种仓鼠来评估病毒脱落的致病性和动力学，与Delta(B.1.617.2)和先前SARS-CoV-2 614G感染后再次感染Omicron BA.1的动物进行比较。与Delta感染的动物相比，感染Omicron BA.1的动物表现出较少的临床体征、病理变化和病毒脱落，但仍显示出肺炎的大体和组织病理学证据。预先存在的免疫力减少了病毒的脱落，并防止了肺炎。我们的数据表明，观察到的疾病严重性的下降部分是由于Omicron BA.1变体的内在特性。
The Omicron BA.1 (B.1.1.529) SARS-CoV-2 variant is characterized by a high number of mutations in the viral genome, associated with immune escape and increased viral spread. It remains unclear whether milder COVID-19 disease progression observed after infection with Omicron BA.1 in humans is due to reduced pathogenicity of the virus or due to pre-existing immunity from vaccination or previous infection. Here, we inoculated hamsters with Omicron BA.1 to evaluate pathogenicity and kinetics of viral shedding, compared to Delta (B.1.617.2) and to animals re-challenged with Omicron BA.1 after previous SARS-CoV-2 614G infection. Omicron BA.1 infected animals showed reduced clinical signs, pathological changes, and viral shedding, compared to Delta-infected animals, but still showed gross- and histopathological evidence of pneumonia. Pre-existing immunity reduced viral shedding and protected against pneumonia. Our data indicate that the observed decrease of disease severity is in part due to intrinsic properties of the Omicron BA.1 variant.
登录
查看更多内容
DOI：
10.1016/s0140-6736(22)00017-4
发表时间：
2022-01-29
期刊：
Lancet (London, England)
影响因子：
--
作者：
Wolter N;Jassat W;Walaza S;Welch R;Moultrie H;Groome M;Amoako DG;Everatt J;Bhiman JN;Scheepers C;Tebeila N;Chiwandire N;du Plessis M;Govender N;Ismail A;Glass A;Mlisana K;Stevens W;Treurnicht FK;Makatini Z;Hsiao NY;Parboosing R;Wadula J;Hussey H;Davies MA;Boulle A;von Gottberg A;Cohen C
通讯作者：
Cohen C
影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1038/s41577-022-00678-4
发表时间：
2022-03
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Sigal A
通讯作者：
Sigal A
影响因子：
24.8
作者：
GeurtsvanKessel CH;Geers D;Schmitz KS;Mykytyn AZ;Lamers MM;Bogers S;Scherbeijn S;Gommers L;Sablerolles RSG;Nieuwkoop NN;Rijsbergen LC;van Dijk LLA;de Wilde J;Alblas K;Breugem TI;Rijnders BJA;de Jager H;Weiskopf D;van der Kuy PHM;Sette A;Koopmans MPG;Grifoni A;Haagmans BL;de Vries RD
通讯作者：
de Vries RD
影响因子：
7.6
作者：
Abdelnabi R;Foo CS;Zhang X;Lemmens V;Maes P;Slechten B;Raymenants J;André E;Weynand B;Dallmeier K;Neyts J
通讯作者：
Neyts J