Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA.2.
Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA.2.
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DOI：
10.1038/s41586-022-04856-1
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发表时间：
2022-07
期刊：
影响因子：
64.8
通讯作者：
中科院分区：
文献类型：
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作者：
最近出现的具有许多突变的SARS-CoV-2 Omicron （B.1.1.529谱系）变体引起了人们对当前针对这些变体的疫苗、治疗性单克隆抗体和COVID-19抗病毒药物有效性下降的担忧。最初的欧米克隆谱系BA.1在许多国家盛行，但最近BA.2在至少68个国家占主导地位。本研究评估了BA.2在免疫正常小鼠和表达ace2的人小鼠和仓鼠中的复制能力和致病性。与最近在祖先WK-521脊骨上表达BA.1和BA.2刺突蛋白的嵌合重组SARS-CoV-2菌株的数据相比，我们观察到BA.2和BA.1在小鼠和仓鼠中的传染性和致病性相似，与早期SARS-CoV-2菌株相比致病性较低。我们还观察到，与祖先株和Delta变异株相比，从COVID-19恢复的个体和接种ba2疫苗的个体的血浆中和活性显著降低。此外，我们发现一些治疗性单克隆抗体（REGN10987 + REGN10933、COV2-2196 + COV2-2130和S309）和抗病毒药物（molnupiravir、nirmatrelvir和S-217622）可以限制ba .2感染仓鼠呼吸器官的病毒感染。这些结果表明，BA.2在啮齿动物中的复制和致病性与BA.1相似，几种治疗性单克隆抗体和抗病毒化合物对Omicron BA.2变异有效。
The recent emergence of SARS-CoV-2 Omicron (B.1.1.529 lineage) variants possessing numerous mutations has raised concerns of decreased effectiveness of current vaccines, therapeutic monoclonal antibodies and antiviral drugs for COVID-19 against these variants. The original Omicron lineage, BA.1, prevailed in many countries, but more recently, BA.2 has become dominant in at least 68 countries. Here we evaluated the replicative ability and pathogenicity of authentic infectious BA.2 isolates in immunocompetent and human ACE2-expressing mice and hamsters. In contrast to recent data with chimeric, recombinant SARS-CoV-2 strains expressing the spike proteins of BA.1 and BA.2 on an ancestral WK-521 backbone, we observed similar infectivity and pathogenicity in mice and hamsters for BA.2 and BA.1, and less pathogenicity compared with early SARS-CoV-2 strains. We also observed a marked and significant reduction in the neutralizing activity of plasma from individuals who had recovered from COVID-19 and vaccine recipients against BA.2 compared to ancestral and Delta variant strains. In addition, we found that some therapeutic monoclonal antibodies (REGN10987 plus REGN10933, COV2-2196 plus COV2-2130, and S309) and antiviral drugs (molnupiravir, nirmatrelvir and S-217622) can restrict viral infection in the respiratory organs of BA.2-infected hamsters. These findings suggest that the replication and pathogenicity of BA.2 is similar to that of BA.1 in rodents and that several therapeutic monoclonal antibodies and antiviral compounds are effective against Omicron BA.2 variants.
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DOI：
10.1038/s41577-022-00676-6
发表时间：
2022-03
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Flemming A
通讯作者：
Flemming A
影响因子：
82.9
作者：
Gruell H;Vanshylla K;Tober-Lau P;Hillus D;Schommers P;Lehmann C;Kurth F;Sander LE;Klein F
通讯作者：
Klein F
DOI：
10.1056/nejmoa2118542
发表时间：
2022-04-14
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hammond J;Leister-Tebbe H;Gardner A;Abreu P;Bao W;Wisemandle W;Baniecki M;Hendrick VM;Damle B;Simón-Campos A;Pypstra R;Rusnak JM;EPIC-HR Investigators
通讯作者：
EPIC-HR Investigators
影响因子：
5.8
作者：
Lubinski B;Fernandes MHV;Frazier L;Tang T;Daniel S;Diel DG;Jaimes JA;Whittaker GR
通讯作者：
Whittaker GR
影响因子：
30.5
作者：
Corbett KS;Werner AP;Connell SO;Gagne M;Lai L;Moliva JI;Flynn B;Choi A;Koch M;Foulds KE;Andrew SF;Flebbe DR;Lamb E;Nurmukhambetova ST;Provost SJ;Bock KW;Minai M;Nagata BM;Ry AV;Flinchbaugh Z;Johnston TS;Mokhtari EB;Mudvari P;Henry AR;Laboune F;Chang B;Porto M;Wear J;Alvarado GS;Boyoglu-Barnum S;Todd JM;Bart B;Cook A;Dodson A;Pessaint L;Steingrebe K;Elbashir S;Sriparna M;Pekosz A;Andersen H;Wu K;Edwards DK;Kar S;Lewis MG;Boritz E;Moore IN;Carfi A;Suthar MS;McDermott A;Roederer M;Nason MC;Sullivan NJ;Douek DC;Graham BS;Seder RA
通讯作者：
Seder RA