A comparison of neighbourhood level variation and risk factors for affective versus non-affective psychosis.
A comparison of neighbourhood level variation and risk factors for affective versus non-affective psychosis.
复制标题
DOI：
10.1016/j.schres.2022.05.015
复制
发表时间：
2023-06
影响因子：
4.5
通讯作者：
Agerbo, Esben
中科院分区：
文献类型：
--
作者：
Schofield, Peter;Horsdal, Henriette Thisted;Das-Munshi, Jayati;Thygesen, Malene;Pedersen, Carsten;Morgan, Craig;Agerbo, Esben
研究通常强调非情感性精神病而非情感性精神病发病率的地区水平差异。我们比较了这两种类型的障碍的邻里水平的变化，以及邻里城市化和种族密度的具体影响，使用丹麦国家登记数据。基于人群的队列（2，224，464人）从1980年到2013年，在15岁时测量邻居暴露，并使用多级泊松回归建模发病率。两种精神障碍的邻里变异相似，非情感性精神病的校正中位风险比为1.37（95%CI 1.34-1.39），情感性精神病的校正中位风险比为1.43（1.38-1.49）。与邻里城市化的关联不同：15岁时生活在最多城市五分之一与最少城市五分之一相比，与随后的情感性精神病的轻微增加相关，IRR 1.13（1.01-1.27），但非情感性精神病的发病率大幅增加，IRR 1.66（1.57-1.75）。邻里族裔密度的结果喜忧参半：对于中东移民，情感性和非情感性的平均发病率增加，IRR为1.54。（1.19-1.99），非情感性精神病，1.13（1.04-1.23）与族裔密度五分位数的每一次下降有关，非洲移民的模式类似，但对于欧洲移民，种族密度似乎只与非情感性精神病有关。虽然整体的变化和邻里的种族密度的影响是类似的两种类型的障碍，与城市化的协会主要局限于非情感性精神病。这可能反映了病因学途径的差异，尽管这些差异背后的机制仍然未知。
Studies typically highlight area level variation in the incidence of non-affective but not affective psychoses. We compared neighbourhood-level variation for both types of disorder, and the specific effects of neighbourhood urbanicity and ethnic density, using Danish national registry data. Population based cohort (2,224,464 people) followed from 1980 to 2013 with neighbourhood exposure measured at age 15 and incidence modelled using multilevel Poisson regression. Neighbourhood variation was similar for both disorders with an adjusted median risk ratio of 1.37 (95% CI 1.34–1.39) for non-affective psychosis and 1.43 (1.38–1.49) for affective psychosis. Associations with neighbourhood urbanicity differed: living in the most compared to the least urban quintile at age 15 was associated with a minimal increase in subsequent affective psychosis, IRR 1.13 (1.01–1.27) but a substantial increase in rates of non-affective psychosis, IRR 1.66 (1.57–1.75). Mixed results were found for neighbourhood ethnic density: for Middle Eastern migrants there was an increased average incidence of both affective, IRR 1.54 (1.19–1.99), and non-affective psychoses, 1.13 (1.04–1.23) associated with each decrease in ethnic density quintile, with a similar pattern for African migrants, but for European migrants ethnic density appeared to be associated with non-affective psychosis only. While overall variation and the effect of neighbourhood ethnic density were similar for both types of disorder, associations with urbanicity were largely confined to non-affective psychosis. This may reflect differences in aetiological pathways although the mechanism behind these differences remains unknown.
登录
查看更多内容
影响因子：
4.4
作者：
Mezuk B;Li X;Cederin K;Concha J;Kendler KS;Sundquist J;Sundquist K
通讯作者：
Sundquist K
影响因子：
3.4
作者：
Mors, Ole;Perto, Gurli P.;Mortensen, Preben Bo
通讯作者：
Mortensen, Preben Bo
影响因子：
6.6
作者：
Kirkbride JB;Jones PB;Ullrich S;Coid JW
通讯作者：
Coid JW
影响因子：
6.9
作者：
Kirkbride, James B.;Morgan, Craig;Jones, Peter B.
通讯作者：
Jones, Peter B.
影响因子：
25.8
作者：
Jongsma, Hannah E.;Gayer-Anderson, Charlotte;Kirkbride, James B.
通讯作者：
Kirkbride, James B.