Distinct Brain Functional Impairment Patterns Between Suspected Non-Alzheimer Disease Pathophysiology and Alzheimer's Disease: A Study Combining Static and Dynamic Functional Magnetic Resonance Imaging.
Distinct Brain Functional Impairment Patterns Between Suspected Non-Alzheimer Disease Pathophysiology and Alzheimer's Disease: A Study Combining Static and Dynamic Functional Magnetic Resonance Imaging.
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疑似非阿尔茨海默病病理生理学与阿尔茨海默病之间的独特脑功能损伤模式：静态和动态功能磁共振成像相结合的研究
DOI：
10.3389/fnagi.2020.550664
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发表时间：
2020
影响因子：
4.8
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative
中科院分区：
文献类型：
--
作者：
Li Z;Li K;Luo X;Zeng Q;Zhao S;Zhang B;Zhang M;Chen Y;Alzheimer’s Disease Neuroimaging Initiative
背景：疑似非阿尔茨海默病病理生理（SNAP）是指β-淀粉样蛋白（Aβ）阴性但tau或神经变性生物标志物阳性的受试者。老年痴呆症占老年人口的四分之一，并与认知能力下降有关。然而，其潜在的病理生理机制尚不清楚。方法：我们纳入了111名非痴呆患者，然后根据脑脊液(CSF) α β 1-42 (A)、磷酸化tau 181 (T)和总tau (N)将其分为三组。具体来说，我们确定了正常对照（NC；生物标志物正常的受试者，A-T- n -）、SNAP（淀粉样蛋白正常但tau蛋白异常的受试者，A−T+）和痴呆前阿尔茨海默病（AD；淀粉样蛋白和tau蛋白异常的受试者，A+T+）。然后，我们用低频波动的静态幅值（sALFF）和动态ALFF （dALFF）方差分别来反映本然功能网络的强度和稳定性。此外，我们还进行了相关分析，以探索大脑内在活动变化与认知之间的可能关系。结果：与NC组相比，SNAP组左侧额上回（SFG）的sALFF降低，左侧岛叶sALFF升高。关于动态指标，与NC相比，SNAP显示左侧SFG和左侧中央旁小叶的dALFF相似地减少。与NC相比，痴呆前AD表现为左侧下顶叶回（IPG）和右侧楔前叶sALFF下降，而左侧岛叶sALFF升高，且dALFF下降的变异在额叶、顶叶和枕叶分布更为广泛。与SNAP直接比较，痴呆前AD表现为左侧枕中回和IPG的sALFF降低，而左侧颞极的dALFF方差降低。进一步的相关分析显示，SNAP组脑岛sALFF升高与一般认知水平呈负相关。此外，痴呆前AD组右侧楔前叶sALFF和dALFF方差与注意力呈负相关。结论：SNAP与痴呆前期AD表现出明显的功能损害模式。具体而言，SNAP具有局限于额叶区域的功能损伤，在早期AD中通常不受影响，而痴呆前AD则表现出广泛分布的涉及额叶、顶叶和枕叶皮层的功能损伤。
Background: Suspected non-Alzheimer disease pathophysiology (SNAP) refers to the subjects who feature negative β-amyloid (Aβ) but positive tau or neurodegeneration biomarkers. It accounts for a quarter of the elderly population and is associated with cognitive decline. However, the underlying pathophysiology is still unclear. Methods: We included 111 non-demented subjects, then classified them into three groups using cerebrospinal fluid (CSF) Aβ 1–42 (A), phosphorylated tau 181 (T), and total tau (N). Specifically, we identified the normal control (NC; subjects with normal biomarkers, A-T-N-), SNAP (subjects with normal amyloid but abnormal tau, A−T+), and predementia Alzheimer’s disease (AD; subjects with abnormal amyloid and tau, A+T+). Then, we used the static amplitude of low-frequency fluctuation (sALFF) and dynamic ALFF (dALFF) variance to reflect the intrinsic functional network strength and stability, respectively. Further, we performed a correlation analysis to explore the possible relationship between intrinsic brain activity changes and cognition. Results: SNAP showed decreased sALFF in left superior frontal gyrus (SFG) while increased sALFF in left insula as compared to NC. Regarding the dynamic metric, SNAP showed a similarly decreased dALFF in the left SFG and left paracentral lobule as compared to NC. By contrast, when compared to NC, predementia AD showed decreased sALFF in left inferior parietal gyrus (IPG) and right precuneus, while increased sALFF in the left insula, with more widely distributed decreased dALFF variance across the frontal, parietal and occipital lobe. When directly compared to SNAP, predementia AD showed decreased sALFF in left middle occipital gyrus and IPG, while showing decreased dALFF variance in the left temporal pole. Further correlation analysis showed that increased sALFF in the insula had a negative correlation with the general cognition in the SNAP group. Besides, sALFF and dALFF variance in the right precuneus negatively correlated with attention in the predementia AD group. Conclusion: SNAP and predementia AD show distinct functional impairment patterns. Specifically, SNAP has functional impairments that are confined to the frontal region, which is usually spared in early-stage AD, while predementia AD exhibits widely distributed functional damage involving the frontal, parietal and occipital cortex.
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影响因子：
5.7
作者：
Fu Z;Tu Y;Di X;Du Y;Pearlson GD;Turner JA;Biswal BB;Zhang Z;Calhoun VD
通讯作者：
Calhoun VD
DOI：
10.1093/brain/awy008
发表时间：
2018-04-01
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Franzmeier N;Düzel E;Jessen F;Buerger K;Levin J;Duering M;Dichgans M;Haass C;Suárez-Calvet M;Fagan AM;Paumier K;Benzinger T;Masters CL;Morris JC;Perneczky R;Janowitz D;Catak C;Wolfsgruber S;Wagner M;Teipel S;Kilimann I;Ramirez A;Rossor M;Jucker M;Chhatwal J;Spottke A;Boecker H;Brosseron F;Falkai P;Fliessbach K;Heneka MT;Laske C;Nestor P;Peters O;Fuentes M;Menne F;Priller J;Spruth EJ;Franke C;Schneider A;Kofler B;Westerteicher C;Speck O;Wiltfang J;Bartels C;Araque Caballero MÁ;Metzger C;Bittner D;Weiner M;Lee JH;Salloway S;Danek A;Goate A;Schofield PR;Bateman RJ;Ewers M
通讯作者：
Ewers M
影响因子：
29
作者：
Gordon BA;Blazey T;Su Y;Fagan AM;Holtzman DM;Morris JC;Benzinger TL
通讯作者：
Benzinger TL
DOI：
10.1007/s00259-019-04536-9
发表时间：
2019-12-02
影响因子：
9.1
作者：
Dodich, Alessandra;Mendes, Aline;Garibotto, Valentina
通讯作者：
Garibotto, Valentina
影响因子：
4.2
作者：
Agosta, Federica;Pievani, Michela;Filippi, Massimo
通讯作者：
Filippi, Massimo