Mannose-binding lectin and maladies of the bowel and liver.
Mannose-binding lectin and maladies of the bowel and liver.
复制标题
甘露糖结合凝集素与肠道和肝脏疾病。
DOI：
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发表时间：
2006
影响因子：
4.3
通讯作者：
C. Mullighan
中科院分区：
文献类型：
--
作者：
D. Worthley;P. Bardy;D. Gordon;C. Mullighan
甘露糖结合凝集素（MBL）是一种模式识别分子，可与许多不同病原体表面存在的特征性碳水化合物基序结合。MBL结合通过补体激活的凝集素途径刺激免疫系统。在某些临床情况下，通常以预先存在的免疫妥协为特征，MBL缺乏增加了感染和其他疾病特异性并发症的风险。许多常见胃肠疾病固有的关键致病过程，如感染、免疫损伤和致癌作用，都与MBL有关。这篇社论回顾了MBL的生物学，概述了关键的疾病协会，以记录MBL的影响范围，最后，强调了MBL与胃肠健康和疾病的相关性。
Mannose-binding lectin (MBL) is a pattern-recognition molecule that binds to characteristic carbohydrate motifs present on the surface of many different pathogens. MBL binding stimulates the immune system via the lectin pathway of complement activation. In certain clinical situations, often characterized by pre-existing immune compromise, MBL deficiency increases the risk of infectious and other disease-specific complications. Many of the key pathogenic processes inherent to common gastroenterological diseases, such as infection, immunological damage, and carcinogenesis, have been linked to MBL. This editorial reviews the biology of MBL, outlines key disease associations to document the breadth of influence of MBL, and finally, highlights the relevance of MBL to both gastroenterological health and disease.
影响因子：
--
作者：
Lee, YH;Witte, T;Sestak, AL
通讯作者：
Sestak, AL
影响因子：
56.9
作者：
GABRIEL, SE;BRIGMAN, KN;STUTTS, MJ
通讯作者：
STUTTS, MJ