Association of prescription H1 antihistamine use with obesity: results from the National Health and Nutrition Examination Survey.
Association of prescription H1 antihistamine use with obesity: results from the National Health and Nutrition Examination Survey.
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DOI：
10.1038/oby.2010.176
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发表时间：
2010-12
期刊：
影响因子：
6.9
通讯作者：
Tek, Cenk
中科院分区：
文献类型：
--
作者：
Ratliff, Joseph C.;Barber, Jessica A.;Palmese, Laura B.;Reutenauer, Erin L.;Tek, Cenk
在美国，肥胖症的发病率已达到流行病的程度。先前的研究表明，几种药物对体重调节具有显着效果。据了解，通常用于缓解过敏症状的组胺 1 (H1) 受体阻滞剂可能会带来体重增加的副作用。因此，我们利用 2005-2006 年国家健康和营养检查调查 (NHANES) 的数据调查了处方 H1 抗组胺药使用与成人肥胖之间的关联。服用处方 H1 抗组胺药的成年人与对照组的年龄和性别相匹配；并根据身体测量值、血浆葡萄糖和胰岛素浓度以及血脂水平进行比较。处方 H1 抗组胺药使用者的体重、腰围和胰岛素浓度均显着高于对照组。处方 H1 抗组胺药使用者的超重比值比 (OR) 增加。 H1 抗组胺药的使用可能会导致成人肥胖和代谢综合征患病率增加，因为这些药物也常被用作非处方药。
The incidence of obesity in the US has reached epidemic proportions. Previous research has shown several medications exert noticeable effects on body weight regulation. Histamine 1 (H1) receptor blockers commonly used to alleviate allergy symptoms are known to report weight gain as a possible side effect. Therefore, we investigated the association between prescription H1 antihistamine use and obesity in adults using data from the 2005–2006 National Health and Nutrition Examination Survey (NHANES). Adults taking prescription H1 antihistamines were matched by age and gender with controls; and compared on the basis of body measurements, plasma glucose and insulin concentrations, and lipid levels. Prescription H1 antihistamine users had a significantly higher weight, waist circumference, and insulin concentration than matched controls. The odds ratio (OR) for being overweight was increased in prescription H1 antihistamine users. H1 antihistamine use may contribute to the increased prevalence of obesity and the metabolic syndrome in adults given these medications are also commonly used as over the counter remedies.
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