Smoking as an independent risk factor for hepatocellular carcinoma: the Singapore Chinese Health Study.
Smoking as an independent risk factor for hepatocellular carcinoma: the Singapore Chinese Health Study.
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吸烟是肝细胞癌的独立危险因素：新加坡中国卫生研究。
DOI：
10.1038/bjc.2011.360
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发表时间：
2011-10-25
影响因子：
8.8
通讯作者：
Yu, M. C.
中科院分区：
文献类型：
--
作者：
Koh, W-P;Robien, K.;Wang, R.;Govindarajan, S.;Yuan, J-M;Yu, M. C.
鉴于大多数流行病学研究中吸烟和饮酒之间的密切相关性，很难排除酒精在吸烟和肝细胞癌（HCC）之间的关联中残留的混杂效应。我们在新加坡华人健康研究（一项酒精摄入率较低的前瞻性队列）中评估了吸烟与肝癌风险之间的关联。有关吸烟和饮酒的信息是通过入学时进行的面对面访谈获得的。经过平均 11.5 年的随访，共有 394 例 HCC 病例。每天饮用超过两杯酒精饮料的参与者患 HCC 的风险增加（风险比 (HR)=2.24；95% 置信区间 (CI)=1.46–3.41）。在调整饮酒量和其他潜在混杂因素后，当前吸烟者与从不吸烟者相比，HCC 风险具有统计学显着性增加（HR=1.63；95% CI=1.27–2.10），且呈剂量依赖性（每天吸烟数量，趋势 P<0.001）。观察到的烟草与 HCC 关联也与持续时间相关（曾经吸烟者的吸烟年数，趋势 P=0.002）。当我们将日常饮酒者排除在分析之外时，所有风险估计基本保持不变且具有统计显着性。我们的研究结果强烈表明烟草烟雾是肝癌发生的一个致病因素。
Given the close correlation between smoking and alcohol intake in most epidemiologic studies, it is difficult to exclude the residual confounding effect of alcohol in the association between smoking and hepatocellular carcinoma (HCC). We evaluated the association between smoking and risk of HCC in the Singapore Chinese Health Study, a prospective cohort with a low prevalence of alcohol intake. Information on cigarette smoking and alcohol consumption was obtained through in-person interviews conducted at enrolment. After a mean of 11.5 years of follow-up, there were 394 incident cases of HCC. Participants who consumed more than two alcoholic drinks per day showed an increased risk for HCC (hazard ratio (HR)=2.24; 95% confidence interval (CI)=1.46–3.41). After adjusting for alcohol consumption and other potential confounders, current vs never smokers had a statistically significant, increased risk of HCC (HR=1.63; 95% CI=1.27–2.10) that was dose-dependent (number of cigarettes per day, P for trend<0.001). The observed tobacco–HCC association also was duration-dependent (years of smoking in ever smokers, P for trend=0.002). When we excluded daily drinkers from the analysis, all risk estimates remained essentially the same and statistically significant. Our findings strongly implicate tobacco smoke as a causal factor of HCC development.
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DOI：
10.1007/s10552-010-9725-0
发表时间：
2011-03
期刊：
Cancer causes & control : CCC
影响因子：
--
作者：
Johnson S;Koh WP;Wang R;Govindarajan S;Yu MC;Yuan JM
通讯作者：
Yuan JM
DOI：
10.1164/rccm.200506-901oc
发表时间：
2006-02-01
影响因子：
24.7
作者：
Butler, LM;Koh, WP;London, SJ
通讯作者：
London, SJ
影响因子：
10.3
作者：
Jee, SH;Ohrr, H;Samet, JM
通讯作者：
Samet, JM
影响因子：
3.8
作者：
Franceschi, S;Montella, M;Talamini, R
通讯作者：
Talamini, R
影响因子：
2.9
作者：
Hankin, JH;Stram, DO;Yu, MC
通讯作者：
Yu, MC