Occurrence of Actinobacillus actinomycetemcomitans and anti-leukotoxin antibodies in some members of an extended family affected by Papillon-Lefèvre syndrome.
Occurrence of Actinobacillus actinomycetemcomitans and anti-leukotoxin antibodies in some members of an extended family affected by Papillon-Lefèvre syndrome.
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受 Papillon-Lefèvre 综合征影响的一些大家族成员中出现放线放线杆菌和抗白细胞毒素抗体。
DOI：
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
W. Soskolne
中科院分区：
文献类型：
--
作者：
A. Stabholz;N. Taichman;W. Soskolne
对一个大家庭的18名成员进行了检查，其中许多人患有Papillon-Lefèvre综合征（PLS）。总共有6名受影响的成员和12名未受影响的成员。所有患者进行了临床检查，其中，在有牙的人，包括牙菌斑指数，探诊出血，探诊深度，牙周附着丧失和一组全口根尖周X光片。同时采集2例患者患牙龈下细菌标本，进行伴放线放线杆菌培养和鉴定。从所有参与者中收集血清样本，并测定抗白细胞毒素抗体。结果表明，白细胞毒性的A.在患有PLS的人以及未受影响的家庭成员中，放线菌共生。A.无处不在。actinomycetemcomitans在科单位中的分布表明A.放线菌共生菌和牙周病相关的综合征;这也表明，A。伴随放线菌本身不足以表达牙周病，其他因素，其中一些必须是遗传的，是病变发展所必需的。
Eighteen (18) members of an extended family in which numerous individuals have Papillon-Lefèvre syndrome (PLS) were examined. In all, 6 affected members and 12 non-affected members were included. All patients underwent a clinical examination which, in the dentate persons, included plaque index, bleeding on probing, probing depth, and periodontal attachment loss and a set of full mouth periapical x-rays. Subgingival bacterial samples were also collected from 2 teeth in the dentate patients for cultures and identification of Actinobacillus actinomycetemcomitans. Serum samples were collected from all participants and assayed for antileukotoxin antibodies. The results indicate that there is a high prevalence of leukotoxic strains of A. actinomycetemcomitans in persons suffering from PLS, as well as in unaffected family members. The ubiquitous presence of A. actinomycetemcomitans in the family units suggests a close association between A. actinomycetemcomitans and the periodontal disease associated with the syndrome; it also suggests that A. actinomycetemcomitans by itself is not sufficient for the expression of periodontal disease and that other factors, some of which must be genetic, are necessary for lesion development.
灵长类动物伴放线放线菌白毒素生物学的比较研究。
影响因子：
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作者：
Taichman,NS;Simpson,DL;Sakurada,S;Cranfield,M;DiRienzo,J;Slots,J
通讯作者：
Slots,J
伴放线放线杆菌在患有成人牙周炎的家庭中的分布和传播。
影响因子：
4.3
作者：
Preus,HR;Zambon,JJ;Dunford,RG;Genco,RJ
通讯作者：
Genco,RJ
Papillon-Lefèvre 综合征：中性粒细胞功能障碍伴严重牙周病。
DOI：
10.1016/0090-1229(84)90094-1
发表时间：
1984
期刊：
Clinical immunology and immunopathology
影响因子：
--
作者：
VanDyke,TE;Taubman,MA;Ebersole,JL;Haffajee,AD;Socransky,SS;Smith,DJ;Genco,RJ
通讯作者：
Genco,RJ