Substance-Specific and Shared Gray Matter Signatures in Alcohol, Opioid, and Polysubstance Use Disorder.
Substance-Specific and Shared Gray Matter Signatures in Alcohol, Opioid, and Polysubstance Use Disorder.
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DOI：
10.3389/fpsyt.2021.795299
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发表时间：
2021
影响因子：
4.7
通讯作者：
Meyerhoff DJ
中科院分区：
文献类型：
--
作者：
Muller AM;Pennington DL;Meyerhoff DJ
物质使用障碍（SUD）已被证明与灰质（GM）损失有关，特别是在额叶皮层。然而，目前尚不清楚这些区域性转基因变异在多大程度上是物质特异性的或在不同物质之间共享的，以及这些区域性转基因变异是相互独立的还是内在连接网络层面的系统级过程的结果。通过数据驱动的顶点和体素GM分析，检查了65例接受治疗的酒精使用障碍（AUD）患者、27例接受维持治疗的阿片类药物使用障碍（OUD）患者、21例接受治疗的兴奋剂使用障碍合并酒精使用障碍（多物质使用障碍患者，PSU）患者和21例健康对照者的T1加权MRI数据。然后，结构协方差分析和开放式fMRI数据库分析被用来映射的皮质变薄模式中发现的三个SUD组到内在的功能系统。在AUD和OUD中，我们确定了右前脑区域常见的皮质变薄以及PSU组中不存在的SUD特异性区域GM改变。此外，AUD患者不仅有最广泛的区域变薄，但也显着较小的皮质下结构和小脑相对于对照组，OUD和PSU个人。系统水平的分析表明，AUD和OUD显示在几个功能系统的皮质变薄。在AUD组中，默认模式网络显然受影响最大，其次是显着性和执行控制网络，而显着性和躯体运动网络被强调为理解OUD的关键。不同SUD组的脑结构改变在空间范围和功能网络相关性方面很大程度上是独特的。
Substance use disorders (SUD) have been shown to be associated with gray matter (GM) loss, particularly in the frontal cortex. However, unclear is to what degree these regional GM alterations are substance-specific or shared across different substances, and if these regional GM alterations are independent of each other or the result of system-level processes at the intrinsic connectivity network level. The T1 weighted MRI data of 65 treated patients with alcohol use disorder (AUD), 27 patients with opioid use disorder (OUD) on maintenance therapy, 21 treated patients with stimulant use disorder comorbid with alcohol use disorder (polysubstance use disorder patients, PSU), and 21 healthy controls were examined via data-driven vertex-wise and voxel-wise GM analyses. Then, structural covariance analyses and open-access fMRI database analyses were used to map the cortical thinning patterns found in the three SUD groups onto intrinsic functional systems. Among AUD and OUD, we identified both common cortical thinning in right anterior brain regions as well as SUD-specific regional GM alterations that were not present in the PSU group. Furthermore, AUD patients had not only the most extended regional thinning but also significantly smaller subcortical structures and cerebellum relative to controls, OUD and PSU individuals. The system-level analyses revealed that AUD and OUD showed cortical thinning in several functional systems. In the AUD group the default mode network was clearly most affected, followed by the salience and executive control networks, whereas the salience and somatomotor network were highlighted as critical for understanding OUD. Structural brain alterations in groups with different SUDs are largely unique in their spatial extent and functional network correlates.
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DOI：
10.1007/s00406-019-01052-7
发表时间：
2021-08-01
影响因子：
4.7
作者：
Bach, Patrick;Frischknecht, Ulrich;Hermann, Derik
通讯作者：
Hermann, Derik
影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
5.7
作者：
Barnes, Josephine;Ridgway, Gerard R.;Fox, Nick C.
通讯作者：
Fox, Nick C.
影响因子：
3.7
作者：
Cole, David M.;Oei, Nicole Y. L.;Beckmann, Christian F.
通讯作者：
Beckmann, Christian F.
影响因子：
4.8
作者：
de la Cruz F;Wagner G;Schumann A;Suttkus S;Güllmar D;Reichenbach JR;Bär KJ
通讯作者：
Bär KJ