Understanding Fibroblast Heterogeneity in Form and Function.
Understanding Fibroblast Heterogeneity in Form and Function.
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DOI：
10.3390/biomedicines11082264
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发表时间：
2023-08-14
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
成纤维细胞在历史上被认为是一种经常被忽视的同质细胞类型，越来越多地被理解为本质上是异质的。虽然成纤维细胞如何参与体内平衡和病理学的机制才刚刚开始被理解，但这些细胞被认为是高度动态的，在纤维化和重塑中起着关键作用。主要集中在皮肤内的成纤维细胞和伤口愈合过程中，我们描述了该领域目前的理解成纤维细胞的异质性的形式和功能。从胚胎起源到解剖变异的差异，我们探讨了成纤维细胞在纤维化和可塑性中的不同贡献。在此之后，我们描述了该领域使用的分子技术，以提供更深入的了解成纤维细胞亚群及其在复杂过程中的各种作用，如伤口愈合。目前工作的局限性也进行了讨论，重点是未来的方向，研究人员建议采取，以获得更深入的了解成纤维细胞生物学和开发潜在的目标，在临床环境中的翻译应用。
Historically believed to be a homogeneous cell type that is often overlooked, fibroblasts are more and more understood to be heterogeneous in nature. Though the mechanisms behind how fibroblasts participate in homeostasis and pathology are just beginning to be understood, these cells are believed to be highly dynamic and play key roles in fibrosis and remodeling. Focusing primarily on fibroblasts within the skin and during wound healing, we describe the field’s current understanding of fibroblast heterogeneity in form and function. From differences due to embryonic origins to anatomical variations, we explore the diverse contributions that fibroblasts have in fibrosis and plasticity. Following this, we describe molecular techniques used in the field to provide deeper insights into subpopulations of fibroblasts and their varied roles in complex processes such as wound healing. Limitations to current work are also discussed, with a focus on future directions that investigators are recommended to take in order to gain a deeper understanding of fibroblast biology and to develop potential targets for translational applications in a clinical setting.
影响因子：
6
作者：
Rajasekar P;Patel J;Clifford RL
通讯作者：
Clifford RL