DNA Methylation of Fibroblast Phenotypes and Contributions to Lung Fibrosis.
DNA Methylation of Fibroblast Phenotypes and Contributions to Lung Fibrosis.
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DOI：
10.3390/cells10081977
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发表时间：
2021-08-03
期刊：
影响因子：
6
通讯作者：
Clifford RL
中科院分区：
文献类型：
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作者：
Rajasekar P;Patel J;Clifford RL
成纤维细胞是结缔组织的组成部分，并通过充当细胞外基质（ECM）的主要来源而在发育和调节组织的结构框架中起关键作用。成纤维细胞的精确定义仍然难以捉摸。肺成纤维细胞协调ECM的组装和周转，以促进气体交换，同时执行免疫功能，包括生物活性分子的分泌和抗原呈递。DNA甲基化是甲基与DNA内的胞嘧啶共价连接。DNA甲基化有助于从相同的潜在遗传序列产生不同的细胞表型，DNA甲基化谱提供了细胞起源的记忆。肺成纤维细胞群体越来越被视为异质性的，迄今为止在健康和肺部疾病中鉴定出6至11个间充质群体。DNA甲基化与健康的不同肺成纤维细胞群体和肺部疾病的改变有关，但程度不同。在这篇综述中，我们将讨论肺成纤维细胞异质性和DNA甲基化对确定细胞群和疾病改变的贡献的证据。
Fibroblasts are an integral part of connective tissue and play a crucial role in developing and modulating the structural framework of tissues by acting as the primary source of extracellular matrix (ECM). A precise definition of the fibroblast remains elusive. Lung fibroblasts orchestrate the assembly and turnover of ECM to facilitate gas exchange alongside performing immune functions including the secretion of bioactive molecules and antigen presentation. DNA methylation is the covalent attachment of a methyl group to primarily cytosines within DNA. DNA methylation contributes to diverse cellular phenotypes from the same underlying genetic sequence, with DNA methylation profiles providing a memory of cellular origin. The lung fibroblast population is increasingly viewed as heterogeneous with between 6 and 11 mesenchymal populations identified across health and lung disease to date. DNA methylation has been associated with different lung fibroblast populations in health and with alterations in lung disease, but to varying extents. In this review, we will discuss lung fibroblast heterogeneity and the evidence for a contribution from DNA methylation to defining cell populations and alterations in disease.
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影响因子：
5.7
作者：
Clifford RL;Yang CX;Fishbane N;Patel J;MacIsaac JL;McEwen LM;May ST;Castellanos-Uribe M;Nair P;Obeidat M;Kobor MS;Knox AJ;Hackett TL
通讯作者：
Hackett TL
影响因子：
4.4
作者：
Bibikova, Marina;Barnes, Bret;Shen, Richard
通讯作者：
Shen, Richard
影响因子：
--
作者：
DERDAK, S;PENNEY, DP;PHIPPS, RP
通讯作者：
PHIPPS, RP
影响因子：
4.4
作者：
Foote, Alexander G.;Wang, Ziyue;Thibeault, Susan L.
通讯作者：
Thibeault, Susan L.
DOI：
10.1038/nrg3849
发表时间：
2015-01
期刊：
Nature reviews. Genetics
影响因子：
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作者：
通讯作者：
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