Temporal trends in incidence of kidney stones among children: a 25-year population based study.
Temporal trends in incidence of kidney stones among children: a 25-year population based study.
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DOI：
10.1016/j.juro.2012.03.021
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发表时间：
2012-07
影响因子：
6.6
通讯作者：
Rule, Andrew D.
中科院分区：
文献类型：
--
作者：
Dwyer, Moira E.;Krambeck, Amy E.;Bergstralh, Eric J.;Milliner, Dawn S.;Lieske, John C.;Rule, Andrew D.
我们进行了一项以人群为基础的儿科研究，以确定25年内症状性肾结石的发病率，并确定与此期间结石发病率变化相关的因素。罗切斯特流行病学项目用于确定1984-2008年明尼苏达州奥姆斯特德县所有诊断为肾结石的儿童（年龄<18岁）。审查医疗记录，以确认首次症状性结石形成者，确定年龄相关症状，并通过成像或传代确认结石。根据年龄、性别和时间段比较症状性结石的发生率。描述了偶发结石形成者的临床特征。有207名儿童接受了肾结石的诊断代码，其中84名（41%）被确认为结石形成者。在整个25年期间，发病率每日历年增加4%（p=0.01）。这是由于12-17岁儿童的发病率每年上升6%（年龄x日历年相互作用p=0.02），从1984-1990年的13/100，000人年增加到2003-2008年的36/100，000人年。1984-1996年，计算机断层扫描（CT）在6%（1/18）的青少年结石形成者中发现了结石，而1997-2008年为76%（34/45）。在这两个时间段之间，青少年自发性结石通过的发生率没有显著增加（16对18/100，000人-年，p=0.30）。在25年的时间段内，一般人群中青少年肾结石的发生率急剧增加。这一发现的确切原因仍有待确定。
We conducted a population-based pediatric study to determine the incidence of symptomatic kidney stones over a 25-year period and to identify factors related to variation in stone incidence during this time period. The Rochester Epidemiology Project was used to identify all children (ages <18 years) diagnosed with kidney stones in Olmsted County, Minnesota from 1984–2008. Medical records were reviewed to validate first time symptomatic stone-formers with identification of age-appropriate symptoms plus stone confirmation by imaging or passage. The incidence of symptomatic stones by age, gender, and time period was compared. Clinical characteristics of incident stone-formers were described. There were 207 children who received a diagnostic code for kidney stones, 84 (41%) of whom were validated as incident stone-formers. The incidence rate increased 4% per calendar year (p=0.01) throughout the 25-year period. This was due to a 6% per year rise of incidence in children aged 12–17 years (p=0.02 for age x calendar year interaction) with an increase from 13 per 100,000 person-years in 1984–1990 to 36 per 100,000 person-years in 2003–2008. Computed tomography (CT) identified the stone in 6% (1/18) of adolescent stone-formers from 1984–1996 versus 76% (34/45) from 1997–2008. The incidence of spontaneous stone passage in adolescents did not increase significantly between these two time periods (16 versus 18 per 100,000 person-years, p=0.30) The incidence of kidney stones increased dramatically among adolescents in the general population over a 25-year period. The exact cause of this finding remains to be determined.
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影响因子：
2.1
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