Light-induced pigment granule migration in the retinular cells of Drosophila melanogaster. Comparison of wild type with ERG-defective mutants.
Light-induced pigment granule migration in the retinular cells of Drosophila melanogaster. Comparison of wild type with ERG-defective mutants.
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DOI：
10.1085/jgp.77.2.155
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发表时间：
1981-02
期刊：
影响因子：
--
通讯作者：
Pak WL
中科院分区：
文献类型：
--
作者：
Lo MV;Pak WL
利用几种视网膜电图（ERG）缺陷突变体，研究了色素颗粒迁移（PGM）对受体电位的依赖性。具有缺陷的层成分但ERG受体成分正常的突变体（没有瞬时a [nonA]和tan）表现出正常的色素颗粒迁移。另一方面，具有非常小或没有受体电位的突变体（某些无受体电位的A [norpA]等位基因）没有表现出PGM。在对温度敏感的norpA突变体norpAH52的情况下，正常的PGM在17℃时存在，而在32℃或更高的温度下不存在，这与它的电生理表型相对应。在瞬时受体电位（trp）突变体中，其受体电位在持续光刺激的几秒钟内衰减到基线，色素颗粒最初在光线打开时靠近横纹肌，但在持续光刺激约5秒后移开。所有这些结果都有力地支持了PGM是由光诱发的受体膜去极化（即受体电位）引发的这一观点。然而，在一定的实验条件下，受体电位未能在trp突变体中诱导PGM。因此，受体的去极化似乎与PGM密切相关，但不是PGM的充分条件。
The dependence of pigment granule migration (PGM) upon the receptor potential was examined using several strains of electroretinogram (ERG)- defective mutants of Drosophila melanogaster. The mutants that have a defective lamina component but a normal receptor component of the ERG (no on-transient A [nonA] and tan) exhibited normal pigment granule migration. The mutants that have very small or no receptor potentials (certain no receptor potential A [norpA] alleles), on the other hand, exhibited no PGM. In the case of the temperature-sensitive norpA mutant, norpAH52, normal PGM was present at 17 degrees but not at 32 degrees C or above, corresponding to its electrophysiological phenotype. In the transient receptor potential (trp) mutant, whose receptor potential decays to the baseline within a few seconds during a sustained light stimulus, the pigment granules initially moved close to the rhabdomere when light was turned on but moved away after about 5 s during a sustained light stimulus. All these results lend strong support to the notion that PGM is initiated by a light-evoked depolarization of the receptor membrane, i.e., the receptor potential. However, under certain experimental conditions, the receptor potentials failed to induce PGM in the trp mutant. The depolarization of the receptor, thus, appears to be closely associated with PGM but is not a sufficient condition for PGM.
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影响因子：
64.8
作者：
HOTTA, Y;BENZER, S
通讯作者：
BENZER, S
影响因子：
5.5
作者：
BROWN, JE;BROWN, PK;PINTO, LH
通讯作者：
PINTO, LH
DOI：
10.1007/bf00696162
发表时间：
1974-01-01
期刊：
JOURNAL OF COMPARATIVE PHYSIOLOGY
影响因子：
--
作者：
BEHRENS, ME
通讯作者：
BEHRENS, ME
影响因子：
2.2
作者：
COSENS, D;PERRY, MM
通讯作者：
PERRY, MM
DOI：
10.1038/newbio244146b0
发表时间：
1973-01-01
期刊：
NATURE-NEW BIOLOGY
影响因子：
--
作者：
BAUMANN, F;MAURO, A
通讯作者：
MAURO, A