Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection.
Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection.
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DOI：
10.1371/journal.pone.0240784
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Conlon N
中科院分区：
文献类型：
--
作者：
Townsend L;Dyer AH;Jones K;Dunne J;Mooney A;Gaffney F;O'Connor L;Leavy D;O'Brien K;Dowds J;Sugrue JA;Hopkins D;Martin-Loeches I;Ni Cheallaigh C;Nadarajan P;McLaughlin AM;Bourke NM;Bergin C;O'Farrelly C;Bannan C;Conlon N
疲劳是有症状的COVID-19感染者的常见症状。然而，尚不清楚COVID-19是否会导致急性感染后恢复的患者持续疲劳。我们使用Chalder疲劳评分（CFQ-11）检查了从COVID-19疾病急性期恢复的个体的疲劳患病率。我们进一步研究了COVID-19感染后疲劳的潜在预测因素，评估了COVID-19严重程度的指标、外周免疫激活的标志物和循环促炎细胞因子。在128名参与者（49.5 ± 15岁; 54%女性）中，超过一半的人在出现初始COVID-19症状后中位10周时报告持续疲劳（67/128; 52.3%）。COVID-19严重程度（需要住院、补充氧气或重症监护）与COVID-19后的疲劳之间没有关联。此外，常规实验室炎症标志物和细胞更新（白细胞、中性粒细胞或淋巴细胞计数、嗜中性粒细胞与淋巴细胞比率、乳酸脱氢酶、C反应蛋白）或促炎分子（IL-6或sCD 25）与COVID-19后疲劳之间无相关性。女性和先前诊断为抑郁/焦虑的患者在疲劳患者中比例过高。我们的研究结果表明，在COVID-19疾病的急性期之后，先前感染过SARS-CoV-2的个体存在明显的病毒后疲劳负担。这项研究强调了评估那些从COVID-19中恢复的人的严重疲劳症状的重要性，无论初始疾病的严重程度如何，并可能确定一个值得进一步研究和早期干预的群体。
Fatigue is a common symptom in those presenting with symptomatic COVID-19 infection. However, it is unknown if COVID-19 results in persistent fatigue in those recovered from acute infection. We examined the prevalence of fatigue in individuals recovered from the acute phase of COVID-19 illness using the Chalder Fatigue Score (CFQ-11). We further examined potential predictors of fatigue following COVID-19 infection, evaluating indicators of COVID-19 severity, markers of peripheral immune activation and circulating pro-inflammatory cytokines. Of 128 participants (49.5 ± 15 years; 54% female), more than half reported persistent fatigue (67/128; 52.3%) at median of 10 weeks after initial COVID-19 symptoms. There was no association between COVID-19 severity (need for inpatient admission, supplemental oxygen or critical care) and fatigue following COVID-19. Additionally, there was no association between routine laboratory markers of inflammation and cell turnover (leukocyte, neutrophil or lymphocyte counts, neutrophil-to-lymphocyte ratio, lactate dehydrogenase, C-reactive protein) or pro-inflammatory molecules (IL-6 or sCD25) and fatigue post COVID-19. Female gender and those with a pre-existing diagnosis of depression/anxiety were over-represented in those with fatigue. Our findings demonstrate a significant burden of post-viral fatigue in individuals with previous SARS-CoV-2 infection after the acute phase of COVID-19 illness. This study highlights the importance of assessing those recovering from COVID-19 for symptoms of severe fatigue, irrespective of severity of initial illness, and may identify a group worthy of further study and early intervention.
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