Sleep phenotyping in a mouse model of extreme trait anxiety.
Sleep phenotyping in a mouse model of extreme trait anxiety.
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DOI：
10.1371/journal.pone.0040625
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Kimura M
中科院分区：
文献类型：
--
作者：
Jakubcakova V;Flachskamm C;Landgraf R;Kimura M
越来越多的证据表明，焦虑会影响睡眠。然而，由于焦虑症的高睡眠变异性，很难陈述由焦虑引起的睡眠参数的特定变化。在具有极高与极低水平特质焦虑的动物模型中进行睡眠分析可能有助于进一步定义与这种精神病理学相关的睡眠模式。在基线和6 h睡眠剥夺（SD）后恢复期间，监测具有高（HAB）、低（LAB）和正常（NAB）焦虑相关行为的小鼠品系的睡眠-觉醒行为24 h。在小鼠品系之间比较每种警觉状态、睡眠结构和EEG频谱变化的量。与NAB小鼠相比，HAB小鼠睡眠时间更多，并且在非快速眼动（NREM）睡眠期间表现出持续增加的Delta功率。他们的睡眠模式的特点是严重的碎片化，减少保持清醒，并频繁侵入快速眼动（REM）睡眠。相比之下，LAB小鼠表现出强大的睡眠-觉醒节律，睡眠潜伏期显著延长，并且持续时间长。此外，与HAB小鼠相比，LAB系SD后Δ功率的积累受损。HAB和LAB小鼠之间的睡眠-觉醒模式存在显著差异，这表明特质焦虑中极端的遗传易感性对睡眠质量留下了生物学疤痕。在HAB小鼠中观察到的增强的睡眠需求，具有对REM睡眠的强烈驱动，可能类似于一种独特的表型，不仅反映了焦虑的升高，而且反映了抑郁样的属性。
There is accumulating evidence that anxiety impairs sleep. However, due to high sleep variability in anxiety disorders, it has been difficult to state particular changes in sleep parameters caused by anxiety. Sleep profiling in an animal model with extremely high vs. low levels of trait anxiety might serve to further define sleep patterns associated with this psychopathology. Sleep-wake behavior in mouse lines with high (HAB), low (LAB) and normal (NAB) anxiety-related behaviors was monitored for 24 h during baseline and recovery after 6 h sleep deprivation (SD). The amounts of each vigilance state, sleep architecture, and EEG spectral variations were compared between the mouse lines. In comparison to NAB mice, HAB mice slept more and exhibited consistently increased delta power during non-rapid eye movement (NREM) sleep. Their sleep patterns were characterized by heavy fragmentation, reduced maintenance of wakefulness, and frequent intrusions of rapid eye movement (REM) sleep. In contrast, LAB mice showed a robust sleep-wake rhythm with remarkably prolonged sleep latency and a long, persistent period of wakefulness. In addition, the accumulation of delta power after SD was impaired in the LAB line, as compared to HAB mice. Sleep-wake patterns were significantly different between HAB and LAB mice, indicating that the genetic predisposition to extremes in trait anxiety leaves a biological scar on sleep quality. The enhanced sleep demand observed in HAB mice, with a strong drive toward REM sleep, may resemble a unique phenotype reflecting not only elevated anxiety but also a depression-like attribute.
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影响因子：
2.4
作者：
Fenzl T;Touma C;Romanowski CP;Ruschel J;Holsboer F;Landgraf R;Kimura M;Yassouridis A
通讯作者：
Yassouridis A
DOI：
10.1073/pnas.1034823100
发表时间：
2003-05-13
影响因子：
11.1
作者：
El Yacoubi, M;Bouali, S;Vaugeois, JM
通讯作者：
Vaugeois, JM
影响因子：
3.8
作者：
ACHERMANN, P;DIJK, DJ;BORBELY, AA
通讯作者：
BORBELY, AA
影响因子：
5.3
作者：
Anaclet, Christelle;Parmentier, Regis;Lin, Jian-Sheng
通讯作者：
Lin, Jian-Sheng
影响因子：
10.6
作者：
Breslau, N;Roth, T;Andreski, P
通讯作者：
Andreski, P