The relationship between nerve conduction velocity and fiber morphology during peripheral nerve regeneration.
The relationship between nerve conduction velocity and fiber morphology during peripheral nerve regeneration.
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DOI：
10.1002/brb3.61
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发表时间：
2012-07
影响因子：
3.1
通讯作者：
Oka, Yoshinori
中科院分区：
文献类型：
--
作者：
Ikeda, Masayoshi;Oka, Yoshinori
关键词：
分析坐骨神经切断后不同时间段运动神经传导速度（MCV）与再生神经纤维形态学变化的关系，以确定可靠的功能恢复指标。将30只大鼠随机分为5组，即对照组和坐骨神经切断后即刻再生50、100、150和200 d组。测量各组的MCV，然后对腓总神经的纤维进行形态学分析。MCV随神经切断后的时间进行性增加，虽然它仍然低于控制速度。平均纤维直径（轴突加髓鞘）也随着时间的推移神经横断后增加。平均纤维直径的恢复与MCV有很好的相关性，即使再生的神经可能含有许多小的非传导性纤维。相比之下，再生轴突的平均直径和相对髓鞘厚度（g-比率）的变化没有提供准确的恢复措施，因为它们没有以时间依赖性的方式增加。此外，在再生神经中，随着纤维直径的增加，节间长度仅略有变化，因此，纤维直径和节间长度之间的回归关系不是一个敏感的恢复指标。MCV和平均纤维直径是反映坐骨神经再生过程中功能恢复的最敏感指标。
We analyzed the relationship between motor nerve conduction velocity (MCV) and morphological changes in regenerating nerve fibers at different times after sciatic nerve transection to identify reliable indices of functional recovery. Thirty rats were divided into five equal groups, one control group and four groups subjected to sciatic nerve transection and immediate suturing, followed by regeneration for 50, 100, 150, and 200 days, respectively. MCV was measured in each group, followed by morphometric analyses of fibers of the common peroneal nerve. MCV increased progressively with time after nerve transection, although it remained lower than the control velocity. Mean fiber diameter (axon plus myelin sheath) also increased with time after nerve transection. Recovery of mean fiber diameter was well correlated with MCV, even though regenerating nerves likely contained many small nonconducting fibers. In contrast, the change in the mean diameter of regenerating axons and relative myelin thickness (g-ratio) did not provide an accurate measure of recovery as they were not increasing in a time-dependent manner. Furthermore, internodal length changed only slightly with increasing fiber diameter in regenerating nerves; therefore, the regression relation between fiber diameter and internodal length was not a sensitive index of recovery. MCV and mean fiber diameter were the most sensitive indices of functional recovery during sciatic nerve regeneration.
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影响因子：
2.9
作者：
SCHRODER, JM
通讯作者：
SCHRODER, JM
影响因子：
11
作者：
BRILL, MH;WAXMAN, SG;JOYNER, RW
通讯作者：
JOYNER, RW
DOI：
10.1097/00005072-198501000-00006
发表时间：
1985-01-01
影响因子：
3.2
作者：
BEUCHE, W;FRIEDE, RL
通讯作者：
FRIEDE, RL
影响因子：
2.5
作者：
Berry, CM;Grundfest, H;Hinsey, JC
通讯作者：
Hinsey, JC
影响因子：
20.6
作者：
LEIFER, LJ;MEYER, MA;PETRIG, B
通讯作者：
PETRIG, B