Suicides by Violent Means in Individuals Taking SSRIs and Other Antidepressants: A Postmortem Study in Sweden, 1992-2004
Suicides by Violent Means in Individuals Taking SSRIs and Other Antidepressants: A Postmortem Study in Sweden, 1992-2004
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服用 SSRIs 和其他抗抑郁药的个体通过暴力手段自杀：瑞典的一项尸检研究，1992-2004 年
DOI：
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发表时间：
2007
影响因子：
2.9
通讯作者：
G. Goodwin
中科院分区：
文献类型：
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作者：
S. Fazel;M. Grann;J. Ahlner;G. Goodwin
许多报告将服用选择性血清素再摄取抑制剂（SSRI）与暴力自杀联系起来。我们的目的是确定与没有检测到抗抑郁药物的自杀相比，有尸检证据表明服用 SSRI 的自杀是否更有可能使用暴力方法。对 1992 年至 2004 年间瑞典所有自杀事件的血样进行了检查。根据警方记录和尸检信息，自杀分为暴力死亡和非暴力（自毒）死亡。此外，我们还调查了死于可检测到三环类药物和其他抗抑郁药物水平的个体中暴力自杀的比例。样本包括 14,691 名自杀者。在 1958 例可检测到 SSRI 水平的自杀事件中，有 1247 例是通过暴力手段自杀的（63.7%），而在未服用抗抑郁药的组中，11,045 例自杀者中有 7835 例（70.9%）（≥21 = 7.6；P < 0.01）。当按性别和年龄范围细分时，我们发现与未服用抗抑郁药物的群体相比，特定群体的暴力自杀比例明显较低，其中包括 15-24 岁的男性。
A number of reports have linked consumption of selective serotonin reuptake inhibitors (SSRIs) with suicide by violent methods. We aimed to determine whether suicides with postmortem evidence of SSRI consumption are more likely to have used violent methods compared with suicides with no detectable antidepressants. Blood samples from all suicides in Sweden during 1992-2004 were examined. Suicides were classified into those who died by violence and nonviolent (self-poisoning) methods using information from police records and autopsy. In addition, we investigated proportions of violent suicide in individuals who died with detectable levels of tricyclic and other antidepressants. The sample consisted of 14,691 suicides. Of the 1958 suicides with detectable levels of SSRIs, 1247 were by violent means (63.7%) compared with 7835 of 11,045 suicides (70.9%) in antidepressant-free group (&khgr;21 = 7.6; P < 0.01). When subdivided by gender and age-bands, we found specific groups with significantly lower proportions of violent suicides compared with the antidepressants-free group, including men aged 15-24 years.
影响因子：
4.8
作者：
Fava, M;Davidson, K;Rosenbaum, JF
通讯作者：
Rosenbaum, JF