An initial study of neural responses to monetary incentives as related to treatment outcome in cocaine dependence.
An initial study of neural responses to monetary incentives as related to treatment outcome in cocaine dependence.
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DOI：
10.1016/j.biopsych.2011.05.008
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发表时间：
2011-09-15
影响因子：
10.6
通讯作者：
Potenza, Marc N.
中科院分区：
文献类型：
--
作者：
Jia, Zhiru;Worhunsky, Patrick D.;Carroll, Kathleen M.;Rounsaville, Bruce J.;Stevens, Michael C.;Pearlson, Godfrey D.;Potenza, Marc N.
关键词：
尽管可卡因依赖涉及与药物相关的基于奖励的决策异常，但尚不清楚这些异常是否泛化为非药物相关的线索和奖励，以及可卡因滥用者奖励处理背后的神经功能如何与治疗结果相关。治疗前 20 名可卡因依赖 (CD) 患者和 20 名匹配的健康对照 (HC) 受试者在执行金钱激励延迟任务 (MIDT) 时参与 fMRI。通过可卡因阴性尿液毒理学百分比、自我报告的可卡因戒断情况和治疗保留情况来评估八周的结果。在整个样本中，对金钱奖励的预期（即奖励预期）与腹侧纹状体（VS）、内侧额回、丘脑、右侧胼胝体下回、右侧岛叶和左侧杏仁核的激活相关。与 HC 参与者相比，CD 参与者在通知奖励结果（即奖励收到）期间，左、右 VS、右尾状核和右岛叶表现出更大的激活。在CD参与者中，在奖励预期期间，左右丘脑和右侧尾状核的激活与可卡因阴性尿液毒理学百分比呈负相关，双侧丘脑的激活与自我报告的戒断措施呈负相关，左侧杏仁核和海马旁回的激活与治疗保留呈负相关。在奖励通知期间，右侧丘脑、右侧 VS 和左侧丘脑的激活与禁欲和尿液毒理学呈负相关。这些发现表明，在寻求治疗的 CD 参与者中，皮质边缘奖励回路在 MIDT 表现期间相对过度激活，与奖励处理相关的特定区域激活可以预测治疗结果的各个方面，并代表 CD 治疗开发的重要目标。
Although cocaine dependence involves abnormalities in drug-related reward-based decision-making, it is not well understood whether these abnormalities generalize to non-drug-related cues and rewards, and how neural functions underlying reward processing in cocaine abusers relate to treatment outcome. Twenty cocaine dependent (CD) patients before treatment and 20 matched healthy control (HC) subjects participated in fMRI while performing a Monetary Incentive Delay Task (MIDT). Outcomes through eight weeks were assessed via percent cocaine-negative urine toxicology, self-reported cocaine abstinence, and treatment retention. Amongst the whole sample, anticipation of working for monetary reward (i.e., reward anticipation) was associated with activation in the ventral striatum (VS), medial frontal gyrus, thalamus, right subcallosal gyrus, right insula, and left amygdala. CD as compared with HC participants exhibited greater activation during notification of rewarding outcome (i.e., reward receipt) in left and right VS, right caudate, and right insula. In CD participants during reward anticipation, activation in left and right thalamus and right caudate correlated negatively with percent cocaine-negative urine toxicology, activation in thalamus bilaterally correlated negatively with self-reported abstinence measures, and activation in left amygdala and parahippocampal gyrus correlated negatively with treatment retention. During reward notification, activation in right thalamus, right VS and left culmen correlated negatively with abstinence and with urine toxicology. These findings suggest that in treatment-seeking CD participants, cortico-limbic reward circuitry is relatively over-activated during MIDT performance and specific regional activations related to reward processing may predict aspects of treatment outcome and represent important targets for treatment development in CD.
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DOI：
10.1111/j.1749-6632.2010.05898.x
发表时间：
2011-01-01
期刊：
ADDICTION REVIEWS
影响因子：
--
作者：
Hommer, Daniel W.;Bjork, James M.;Gilman, Jodi M.
通讯作者：
Gilman, Jodi M.
影响因子：
56.9
作者：
Canli, T;Sivers, H;Gabrieli, JDE
通讯作者：
Gabrieli, JDE
影响因子：
10.6
作者：
Freire, L;Roche, A;Mangin, JF
通讯作者：
Mangin, JF
影响因子：
6.9
作者：
Chamberlain, Samuel R.;Sahakian, Barbara J.
通讯作者：
Sahakian, Barbara J.
影响因子：
16.2
作者：
Breiter, HC;Aharon, I;Shizgal, P
通讯作者：
Shizgal, P