THRB genetic polymorphisms can predict severe myelotoxicity after definitive chemoradiotherapy in patients with esophageal squamous cell carcinoma.
THRB genetic polymorphisms can predict severe myelotoxicity after definitive chemoradiotherapy in patients with esophageal squamous cell carcinoma.
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DOI：
10.7150/ijms.5081
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发表时间：
2012
影响因子：
3.6
通讯作者：
Sakaeda T
中科院分区：
文献类型：
--
作者：
Miki I;Nakamura T;Kuwahara A;Yamamori M;Nishiguchi K;Tamura T;Okuno T;Omatsu H;Mizuno S;Hirai M;Azuma T;Sakaeda T
目的：化疗相关毒副反应在治疗前难以预测。在这项研究中，我们调查了甲状腺激素受体β(THRB)基因多态性是否可以作为潜在的生物标记物在食管鳞癌(ESCC)患者中。方法：对49例接受5-氟尿嘧啶和顺铂联合放射治疗的日本食管癌患者进行回顾性分析。根据rs7635707G/T、rs6787255 A/C、rs9812034G/T、rs9310738C/T内含子SNPs，以及rs844107C/T和rs1349265G/A基因3‘非翻译区(3’-UTR)的SNPs，对严重急性白血病患者的白细胞减少、口腔炎、唇炎等严重急性毒性反应进行评估。口腔炎和唇炎与所分析的6个SNP中的任何一个都没有关联。4个内含子SNPs的单倍型频率约为97%，其中G-A-G-C(73.4%)和T-C-T-T(23.5%)是两种主要单倍型。结论：THRB基因内含子SNPs可以为ESCC患者CRT相关的严重骨髓毒性提供有用的信息。还需要进一步的研究来证实这些发现。
Objective: Chemotherapy-related toxicities are difficult to predict before treatment. In this study, we investigated whether thyroid hormone receptor beta (THRB) genetic polymorphisms can serve as a potential biomarker in patients with esophageal squamous cell carcinoma (ESCC). Methods: Forty-nine Japanese patients with ESCC who received a definitive chemoradiotherapy (CRT) with 5-fluorouracil and cisplatin in conjunction with concurrent irradiation were retrospectively analyzed. Severe acute toxicities, including leukopenia, stomatitis, and cheilitis, were evaluated according to 6 single nucleotide polymorphisms (SNPs) in the gene; the intronic SNPs of rs7635707 G/T, rs6787255 A/C, rs9812034 G/T, and rs9310738 C/T and the SNPs in the 3′-untranslated region (3′-UTR) of rs844107 C/T and rs1349265 G/A. Results: Distribution of the 4 intronic SNPs, but not the 2 SNPs in the 3′-UTR, showed a significant difference between patients with and without severe acute leukopenia. Stomatitis and cheilitis were not associated with any of the 6 analyzed SNPs. Frequency of haplotype of the 4 intronic SNPs reached approximately 97% with the 2 major haplotypes G-A-G-C (73.4%) and T-C-T-T (23.5%). Conclusions: THRB intronic SNPs can provide useful information on CRT-related severe myelotoxicity in patients with ESCC. Future studies will be needed to confirm these findings.
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DOI：
10.1677/joe-08-0539
发表时间：
2009-11
期刊：
The Journal of endocrinology
影响因子：
--
作者：
Amorim BS;Ueta CB;Freitas BC;Nassif RJ;Gouveia CH;Christoffolete MA;Moriscot AS;Lancelloti CL;Llimona F;Barbeiro HV;de Souza HP;Catanozi S;Passarelli M;Aoki MS;Bianco AC;Ribeiro MO
通讯作者：
Ribeiro MO
影响因子：
3.7
作者：
López-Fontal R;Zeini M;Través PG;Gómez-Ferrería M;Aranda A;Sáez GT;Cerdá C;Martín-Sanz P;Hortelano S;Boscá L
通讯作者：
Boscá L
影响因子：
5.8
作者：
Kawa, Milosz Piotr;Grymula, Katarzyna;Machalinski, Boguslaw
通讯作者：
Machalinski, Boguslaw
影响因子：
8.5
作者：
Grymula, K.;Paczkowska, E.;Machalinski, B.
通讯作者：
Machalinski, B.
由于食管的T3或T4鳞状细胞癌引起的恶性狭窄患者的明确化学放射疗法。
影响因子：
8.8
作者：
Kaneko K;Ito H;Konishi K;Kurahashi T;Ito T;Katagiri A;Yamamoto T;Kitahara T;Mizutani Y;Ohtsu A;Mitamura K
通讯作者：
Mitamura K