Ligation strategies for targeting liposomal nanocarriers.

Ligation strategies for targeting liposomal nanocarriers.
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DOI:
10.1155/2014/129458
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发表时间:
2014
影响因子:
--
通讯作者:
de Kroon AI
de Kroon AI
中科院分区:
生物学3区
文献类型:
--
作者:
Marqués-Gallego P;de Kroon AI

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Liposomes have been exploited for pharmaceutical purposes, including diagnostic imaging and drug and gene delivery. The versatility of liposomes as drug carriers has been demonstrated by a variety of clinically approved formulations. Since liposomes were first reported, research of liposomal formulations has progressed to produce improved delivery systems. One example of this progress is stealth liposomes, so called because they are equipped with a PEGylated coating of the liposome bilayer, leading to prolonged blood circulation and improved biodistribution of the liposomal carrier. A growing research area focuses on the preparation of liposomes with the ability of targeting specific tissues. Several strategies to prepare liposomes with active targeting ligands have been developed over the last decades. Herein, several strategies for the functionalization of liposomes are concisely summarized, with emphasis on recently developed technologies for the covalent conjugation of targeting ligands to liposomes.
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