Risks and benefits of psilocybin use in people with bipolar disorder: An international web-based survey on experiences of 'magic mushroom' consumption.
Risks and benefits of psilocybin use in people with bipolar disorder: An international web-based survey on experiences of 'magic mushroom' consumption.
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DOI：
10.1177/02698811221131997
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发表时间：
2023-01
影响因子：
4.1
通讯作者：
Woolley, Josh
中科院分区：
文献类型：
--
作者：
Morton, Emma;Sakai, Kimberly;Ashtari, Amir;Pleet, Mollie;Michalak, Erin E.;Woolley, Josh
裸盖菇素是迷幻药“神奇蘑菇”的主要精神活性成分，可能具有治疗抑郁症状的潜力，并因此应用于双相情感障碍（BD）。裸盖菇素在BD中的风险和益处的知识仅限于病例研究。为了支持临床试验的设计，我们调查了BD患者使用裸盖菇素的经验。一项基于网络的国际调查被用来探索裸盖菇素在自我报告诊断为BD的人中的使用经验。使用描述性统计量总结定量结果。定性内容分析被用来调查自由文本的反应，重点是积极的经验，裸盖菇素使用。共有541人完成了调查（46.4%为女性，平均年龄34.1岁）。三分之一（32.2%; n = 174）的受访者描述了新的/增加的症状后，psilocybin旅行，突出躁狂症状，睡眠困难和焦虑。与BD II相比，BD I个体的总体不良事件发生率无差异。使用紧急医疗服务是罕见的（n = 18; 3.3%），受访者（即使是那些谁经历了不良反应）表示，裸盖菇素的使用是有益的比有害的。定量研究结果阐述了感知的好处，以及潜在的psilocybin行程包含积极和消极的收到的元素。调查参与者报告的使用裸盖菇素治疗精神健康症状的主观益处鼓励进一步调查基于裸盖菇素的BD治疗。临床试验应包括对症状的仔细监测，因为数据表明BD症状可能在使用裸盖菇素后出现或加剧。
Psilocybin, the primary psychoactive component of psychedelic ‘magic mushrooms’, may have potential for treating depressive symptoms, and consequent applications for bipolar disorder (BD). Knowledge of the risks and benefits of psilocybin in BD is limited to case studies. To support the design of clinical trials, we surveyed experiences of psilocybin use in people with BD. An international web-based survey was used to explore experiences of psilocybin use in people with a self-reported diagnosis of BD. Quantitative findings were summarised using descriptive statistics. Qualitative content analysis was used to investigate free-text responses, with a focus on positive experiences of psilocybin use. A total of 541 people completed the survey (46.4% female, mean 34.1 years old). One-third (32.2%; n = 174) of respondents described new/increasing symptoms after psilocybin trips, prominently manic symptoms, difficulties sleeping and anxiety. No differences in rates of adverse events overall were observed between individuals with BD I compared to BD II. Use of emergency medical services was rare (n = 18; 3.3%), and respondents (even those who experienced adverse effects) indicated that psilocybin use was more helpful than harmful. Quantitative findings elaborated on perceived benefits, as well as the potential for psilocybin trips to contain both positively and negatively received elements. The subjective benefits of psilocybin use for mental health symptoms reported by survey participants encourage further investigation of psilocybin-based treatments for BD. Clinical trials should incorporate careful monitoring of symptoms, as data suggest that BD symptoms may emerge or intensify following psilocybin use.
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影响因子：
6.6
作者：
Bonnin, C. M.;Sanchez-Moreno, J.;Torrent, C.
通讯作者：
Torrent, C.
影响因子：
25.8
作者：
Davis AK;Barrett FS;May DG;Cosimano MP;Sepeda ND;Johnson MW;Finan PH;Griffiths RR
通讯作者：
Griffiths RR
影响因子：
3.8
作者：
Gorman I;Nielson EM;Molinar A;Cassidy K;Sabbagh J
通讯作者：
Sabbagh J
DOI：
10.1177/0269881116675513
发表时间：
2016-12
期刊：
Journal of psychopharmacology (Oxford, England)
影响因子：
--
作者：
Griffiths RR;Johnson MW;Carducci MA;Umbricht A;Richards WA;Richards BD;Cosimano MP;Klinedinst MA
通讯作者：
Klinedinst MA
影响因子：
5.4
作者：
Adida, Marc;Clark, Luke;Goodwin, Guy M.
通讯作者：
Goodwin, Guy M.