Inhaled steroids associated with decreased macrophage markers in nonasthmatic individuals with sickle cell disease in a randomized trial.
Inhaled steroids associated with decreased macrophage markers in nonasthmatic individuals with sickle cell disease in a randomized trial.
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DOI：
10.1007/s00277-019-03635-9
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发表时间：
2019-04
影响因子：
3.5
通讯作者：
Glassberg J
中科院分区：
文献类型：
--
作者：
Langer AL;Leader A;Kim-Schulze S;Ginzburg Y;Merad M;Glassberg J
在一项针对镰状细胞病非哮喘患者的随机对照试验中，吸入莫米松可改善疼痛评分，降低可溶性血管细胞粘附分子（sVCAM）浓度。我们试图探索全身炎症的潜在变化作为这种效应的机制。在基线和莫米松治疗8周后，使用92个炎症标志物组分析了41名试验参与者（15名安慰剂组和26名莫米松治疗组）的血清样本。进行个体标记分析和相关分析。经年龄校正后，莫米松治疗组与安慰剂治疗组相比，CXCL 9、CXCL 11、CD 40、IL-10和IL-18的浓度降低。分层聚类和相关性分析确定了与巨噬细胞信号传导和迁移相关的细胞因子减少的额外证据。哮喘和过敏的标志物没有统计学显著变化，表明这种改善不太可能是由隐匿性反应性气道疾病的调节介导的。对炎症标志物的分析表明，巨噬细胞活性的降低可能与镰状细胞病非哮喘患者吸入莫米松的临床获益有关。
Inhaled mometasone was shown to improve pain scores and decrease soluble vascular cell adhesion molecule (sVCAM) concentration in a randomized controlled trial of nonasthmatic patients with sickle cell disease. We sought to explore potential changes in systemic inflammation as a mechanism underlying this effect. Serum samples from 41 trial participants (15 placebo- and 26 mometasone-treated) were analyzed using a 92 inflammatory marker panel at baseline and after 8 weeks of mometasone therapy. Individual marker analysis and correlation analysis were conducted. Adjusted for age, the mometasone-treated group decreased the concentration of CXCL9, CXCL11, CD40, IL-10, and IL-18 relative to placebo-treated participants. Hierarchical clustering and correlation analysis identified additional evidence for a decrease in cytokines linking to macrophage signaling and migration. There was no statistically significant change in markers of asthma and allergy, indicating that the improvement was unlikely mediated by modulation of occult reactive airway disease. This analysis of inflammatory markers suggests that decrease in macrophage activity may be involved in the mediation of the clinical benefit seen with use of inhaled mometasone in nonasthmatic patients with sickle cell disease.
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影响因子：
2.9
作者：
Keegan PM;Surapaneni S;Platt MO
通讯作者：
Platt MO
影响因子：
3.6
作者：
Glassberg JA;Strunk R;DeBaun MR
通讯作者：
DeBaun MR
影响因子：
5.5
作者：
Lanaro, C.;Franco-Penteado, C. F.;Costa, F. F.
通讯作者：
Costa, F. F.
DOI：
10.4049/jimmunol.1302269
发表时间：
2014-03-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Cai Y;Sugimoto C;Arainga M;Alvarez X;Didier ES;Kuroda MJ
通讯作者：
Kuroda MJ
与对照组相比，在患有镰状细胞疾病的儿童中喘息很常见。
DOI：
10.1097/mph.0000000000000239
发表时间：
2015-01
期刊：
Journal of pediatric hematology/oncology
影响因子：
--
作者：
Galadanci NA;Liang WH;Galadanci AA;Aliyu MH;Jibir BW;Karaye IM;Inusa BP;Vermund SH;Strunk RC;DeBaun MR
通讯作者：
DeBaun MR