Oxygen tension changes the rate of migration of human skin keratinocytes in an age-related manner.
Oxygen tension changes the rate of migration of human skin keratinocytes in an age-related manner.
复制标题
氧张力以与年龄相关的方式改变人类皮肤角质形成细胞的迁移速率。
DOI：
10.1111/j.1600-0625.2010.01190.x
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发表时间：
2011-01
影响因子：
3.6
通讯作者：
Aykin-Burns N
中科院分区：
文献类型：
--
作者：
Ross C;Alston M;Bickenbach JR;Aykin-Burns N
Migration of keratinocytes to re-epithelialize wounds is a key step in dermal wound healing. In aged human skin, wound healing rates decrease and cellular damage by reactive oxygen species (ROS) accumulates. The relationship between age, ROS and human skin keratinocyte migration is not clearly understood. In this study, 4% and 21% oxygen tensions were used to modify levels of ROS produced by metabolism to model low and high oxidative stress conditions. When migration of keratinocytes from young and old primary skin was compared using an in vitro scratch assay, old keratinocytes migrated faster in high oxygen tension than did young keratinocytes, whereas young keratinocytes migrated faster in low oxygen tension. Although all young and old cells at the scratch margins showed intense increases in dihydroethidium oxidation immediately after scratching, the old keratinocytes grown at 21% oxygen demonstrated a greater decrease in the DHE oxidation following scratching and migrated the fastest. These results show that old and young keratinocytes respond to oxygen tension differently and support the hypothesis that keratinocyte migration is affected by the capacity to remove ROS.
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影响因子：
7.4
作者：
Khodr, B;Khalil, Z
通讯作者：
Khalil, Z
影响因子：
12.4
作者：
Roy, S;Khanna, S;Sen, CK
通讯作者：
Sen, CK
影响因子：
--
作者：
Engeland, Christopher G.;Bosch, Jos A.;Marucha, Phillip T.
通讯作者：
Marucha, Phillip T.
DOI：
10.1111/j.1749-6632.2001.tb05631.x
发表时间：
2001-01-01
期刊：
HEALTHY AGING FOR FUNCTIONAL LONGEVITY
影响因子：
--
作者：
Harman, D
通讯作者：
Harman, D
影响因子：
3.6
作者：
Marin, Yari E.;Seiberg, Miri;Lin, Connie B.
通讯作者：
Lin, Connie B.