Differential roles of human striatum and amygdala in associative learning.

Differential roles of human striatum and amygdala in associative learning.
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DOI:
10.1038/nn.2904
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发表时间:
2011-09-11
影响因子:
25
通讯作者:
Daw ND
Daw ND
中科院分区:
医学1区
文献类型:
--
作者:
Li J;Schiller D;Schoenbaum G;Phelps EA;Daw ND

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尽管人类的杏仁核和纹状体都与联想学习有关,但只有纹状体的贡献得到了一致的计算特征。通过逆向学习任务,我们证明了杏仁核BOLD活动跟踪由计算模型估计的关联性,并将其与强化预测误差的纹状体表示分离开来。这些结果将计算学习方法从纹状体扩展到杏仁体,证明了它们在厌恶学习中的互补作用。
Although the human amygdala and striatum have both been implicated in associative learning, only the striatum’s contribution has been consistently computationally characterized. Using a reversal learning task, we demonstrate that amygdala BOLD activity tracks associability as estimated by a computational model, and dissociates it from the striatal representation of reinforcement prediction error. These results extend the computational learning approach from striatum to amygdala, demonstrating their complementary roles in aversive learning.
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